roughness and viscoelastic effects to the measured damping values are estimated.Electrocatalytic oxidation of water (i.e., oxygen evolution reaction, OER) plays crucial roles in energy, environment, and biomedicine. It is a key factor affecting the efficiencies of electrocatalytic reactions conducted in aqueous solution, e.g., electrocatalytic water splitting and glucose oxidation reaction (GOR). However, electrocatalytic OER still suffers from problems like high overpotential, sluggish kinetics, and over-reliance on expensive noble-metal-based catalysts. Herein, 15 nm thick carbon-based shell coated tungsten oxide (CTO) nanospheres are loaded on nickel foam to form CTO/NF. An enhanced electrocatalytic OER is triggered on CTO/NF, with the overpotential at 50 mA cm-2 (317 mV) and the Tafel slope (70 mV dec-1) on CTO/NF lower than those on pure tungsten oxide (360 mV, 117 mV dec-1) and noble-metal-based IrO2 catalysts (328 mV, 96 mV dec-1). A promoted electrocatalytic GOR is also achieved on CTO/NF, with efficiency as high as 189 μA mM-1 cm-2. The carbon-based shell on CTO is flexible for electron transfer between catalyst and reactants and provides catalytically active sites. This improves reactant adsorption and O-H bond dissociation on the catalyst, which are key steps in OER and GOR. The carbon-based shell on CTO retains the catalyst as nanospheres with a higher surface area, which facilitates OER and GOR. It is the multiple roles of the carbon-based shell that increases the electrocatalytic efficiency. These results are helpful for fabricating more efficient noble-metal-free electrocatalysts.ADP-mediated platelet aggregation is signaled through G protein-coupled receptors P2Y1 and P2Y12 on the platelet. The clinical effectiveness of inhibiting P2Y12 has been well established, and preclinical studies indicated that the inhibition of P2Y1 could provide equivalent antithrombotic efficacy as P2Y12 antagonists and reduce bleeding risks. On the basis of the 2-phenyl-1H-imidazole scaffold of our previously reported xanthine oxidase inhibitor WSJ-557, we first achieved the transition from the xanthine oxidase inhibitors to dual-target antagonists against P2Y1 and P2Y12.  https://www.selleckchem.com/products/CP-690550.html  We described the structure-activity relationships of the 2-phenyl-1H-imidazole compounds, which led to the identification of the most potent antiplatelet agents, 24w and 25w, both showing a rapid onset of action in pharmacokinetic study. Furthermore, the rat model suggested that 24w demonstrated a wider therapeutic window than ticagrelor, displaying equivalent and dose-dependent antithrombotic efficacy with lower blood loss compared to ticagrelor at same oral dose. These results supported that 24w and 25w could be promising drug candidates.Herein, one kind of neutral chiral zirconium metal-organic framework (Zr-MOF) was reported from the porphyrinic MOF (PMOF) family with a metallolinker (MnIII-porphyrin) as the achiral polytopic linker [free base tetrakis(4-carboxyphenyl)porphyrin] and chiral anions. Achiral Zr-MOF was chiralized through the exchange of primitive anions with new chiral organic anions (postsynthetic exchange). This chiral functional porphyrinic MOF (CPMOF) was characterized by several techniques such as powder X-ray diffraction, Fourier transform infrared spectroscopy, ultraviolet-visible spectroscopy, 1H NMR, energy-dispersive X-ray spectroscopy, scanning electron microscopy, and Brunauer-Emmett-Teller measurements. In the resulting structure, there are two active metal sites as Lewis acid centers (Zr and Mn) and chiral species as Brønsted acid sites along with their cooperation as nucleophiles. This CPMOF shows considerable bimodal porosity with high surface area and stability. Additionally, its ability was investigated in asymmetric catalyses of prochiral substrates. Interactions between framework chiral species and prochiral substrates have large impacts on the catalytic ability and chirality induction. This chiral catalyst proceeded asymmetric epoxidation and CO2 fixation reactions at lower pressure with high enantioselectivity due to Lewis acids and chiral auxiliary nucleophiles without significant loss of activity up to the sixth step of consecutive cycles of reusability. Observations revealed that chiralization of Zr-MOF could happen by a succinct strategy that can be a convenient method to design chiral MOFs.The presence of anthropogenically emitted chlorinated paraffins (CPs) has been reported in the pristine regions, providing evidence of their long-range transport. This study comprehensively analyzed the short-chain chlorinated paraffins (SCCPs) and medium-chain chlorinated paraffins (MCCPs) in both gas and particle phases at King George Island, West Antarctica (the Chinese Great Wall Station), from 2014 to 2018. The atmospheric levels of CPs ranged between 71.4 and 4230 pg/m3, with an increasing temporal trend during the sampling time. Three different models (J-P model, H-B model, and L-M-Y model) were built to estimate the progress of gas/particle partitioning of CPs at the measurement site. Furthermore, we compared the measured data of the gas/particle partitioning with the data estimated using three different models. We found that the steady-state model (L-M-Y model) was more suitable for investigating the gas/particle partitioning of CPs instead of equilibrium state models (J-P model and H-B model). The result indicated that steady-state approximation rather than the equilibrium state represents the most predominant contribution to the transport of CPs to the Antarctic region. The steady-state further made it conducive to sustaining the levels of CPs for a more extended period in the atmosphere of West Antarctica.Using 2,2'-R2-biphenyl-4,4'-dicarboxylic acid to bind with a cis-[InO4(μ2-OH)2] octahedron, three novel chiral 3D indium-organic frameworks, [In(μ2-OH)L] [1, L1, R = N(CH3)2; 2, L2, R = OCH3; 3, L3, R = CH3], have been hydrothermally synthesized without chiral reagents. Crystal structure analyses reveal that 1-3 show an unprecedented 4-connected umy topology with the Schläfli symbol (42·64). 1 exhibits high water stability and good sorption selectivity of CO2 over N2, while 3 displays high C2H2, C2H4, and C2H6 uptake capacity at 273 K.