other AML-MRC.Primary Ewing sarcoma (ES) of the urinary bladder is a rare and aggressive small blue round cell malignant neoplasm associated primarily with translocation involving EWSR1 and FLI1 genes located in the 22nd and 11th chromosomes, respectively. To date, 18 cases have been published in the literature as single-case reports, based chiefly on CD99 positivity (17 patients). Molecular confirmation by fluorescence in situ hybridization was performed in 9 patients, and FLI1 immunohistochemical (IHC) analysis was not performed in any of these published cases. Herein, we present thirteen patients of more comprehensive primary round cell sarcomas of the urinary bladder with EWSR1 rearrangement. Clinicopathologic parameters including demographics; clinical presentation; histopathologic, IHC, and molecular profiles; and management and follow-up data of 13 patients with primary round cell sarcomas with EWSR1 rearrangement (Ewing family of tumor) of the urinary bladder were analyzed. The studied patients (n = 13) included 6 ing from 5 to 24 months). Six patients either died of disease (n = 3) or other causes (n = 3). Five patients were alive with metastases to the liver (n = 1), liver and lung (n = 2), liver and abdominal wall (n = 1), and kidney (n = 1). Based on our experience with the largest series to date and aggregate of the published data, ES/round cell sarcomas with EWSR1 rearrangement occurring in the bladder have bimodal age distribution with poor prognosis despite aggressive therapy. Owing to its rarity and age distribution, the differential diagnosis is wide and requires a systematic approach for ruling out key age-dependent differential diagnoses aided with molecular confirmation.Wound management has attracted significant interest in view of the broad demand market. Dressings are playing crucial roles in wounds management because they can protect the wound from external infection, and accelerate the healing process. Among the various available dressing materials, hydrogels have appealed increasing attention for their tunable chemical, physical and biological properties, and three-dimensional cross-linked polymer networks which can absorb and retain large amount of water. Although hydrogels have become representative of soft dressing materials, the design of conventional hydrogel materials still needs improvement. Nowadays, novel self-healing hydrogel wound dressings hopefully optimize the defects of mechanical property over conventional hydrogel thus extend their usage lifespan due to their potential of autonomous self-recovery against damage, which have gained much momentum recently. This presented review mainly focuses on research status of self-healing hydrogel for wound management. The polymers suitable for hydrogel forming, and the appropriate molecular design of the hydrogel network for achieving self-healing properties are discussed, followed by the applications of self-healing hydrogel as wound dressing. Finally, we discuss the future perspectives of self-healing hydrogel as wound dressing, and provide the recommendations for its possible developing orientation.Dry modification of starch, especially by microwave-assisted heating, has attracted increasing attention due to its various advantages, including energy saving, high conversion, rapidity, and avoidance of volatile organic solvents in organic synthesis. This work focuses on two fundamental issues 1) effect of starch microstructure on dry modification; 2) effect of acid anhydride in solid and liquid states on the dry reaction, since their interfaces with solid starch are significantly different. Cornstarches with different amylose/amylopectin ratios were used to demonstrate the effect of starch microstructure, while two acid anhydrides, maleic (solid) and acetic (liquid) anhydrides, were used to study the reaction mechanisms. FTIR, SEM, XRD, and DSC were used to study the performance of modified starches and the mechanisms. It was found that the degree of substitution (DS) of starches modified by maleic anhydride generally increased with increasing amylose content since amylose contains more hydroxyl groups, resulting in higher sensitivity to microwaves. On the other hand, the DS of starches modified by acetic anhydride increased with increasing amylopectin content, since liquid acetic acid can diffuse into high-amylopectin starch granules. The higher amylopectin starches, waxy and maize, showed higher RC(%) and ∆H(%) than that of higher amylose starches G50 and G80.The current drugs for treating Leishmaniasis are toxic, non-economical and with the emergence of drug resistance makes the need for novel therapeutics urgent and necessary. In the current study, we report the identification of compounds TI 1-5 against tyrosine aminotransferase of L. donovani from a curated ZINC15 database containing 183,659 compounds. These flavonoid compounds had binding energies less then -8 kcal/mol and interacted with the active site residues S151, K286, C290, and P291. Assessment of physicochemical descriptors and ADMET properties established the drug likeliness of these compounds. The all-atom molecular dynamic simulations of the TAT-TI complexes exhibited stable geometrical properties and further trajectory analysis revealed the high-affinity interactions of TI 1, 3, 4, and 5 with the active site residues. DFT calculations reported the high electrophilic nature of TI 2 while other TI compounds demonstrated good kinetic stability and reactivity. From in vitro studies, TI 3 and TI 4 had the highest inhibition with Ki values of 0.9 ± 0.2 μM and 0.30 ± 0.1 μM, respectively. Taken together, the results from this study indicate the potentiality of TI 1, 3, 4, and 5 as anti-leishmanial leads, and these compounds can be exploited to manage the growing Leishmaniasis crisis in the world.The purpose of this study is to investigate the natural Luffa vine (LV) fiber to be effectively used as cellulose fiber reinforcing material for lightweight and decay-resistance composite materials. The physical, chemical, thermal, and morphological properties of the LV fibers, together with their microstructure are investigated. The test results conclude that the LV density, microscopic characteristics, and mechanical properties show that this crop is a lightweight (200-550 kg/m3) natural fiber with a porous structure and a high specific modulus (1.18-2.04 MPa∙ m3/kg). The chemical, X-ray diffraction and the Fourier transform infrared spectroscopy analyses indicate that the LV has a high lignin content (25.18%) and a relatively high relative crystallinity (37.18%) of cellulose, and it contains saponins, which increase its erosion resistance and hardness.  https://www.selleckchem.com/products/atogepant.html  The thermogravimetric analysis reveals that the fibers can stand up to 315.4 °C. Moreover, due to their kinetic activation energy of 63.9 kJ/mol, they can be used as reinforcement materials in thermoplastic green composites with a working temperature below 300°.