https://www.selleckchem.com/products/erastin.html ection and the mechanisms used by these viruses to avoid clearance through the autophagic pathway. Our study highlights the importance of the host factor BPIFB3 in regulating flavivirus replication and further confirms that the RETREG1-dependent reticulophagy pathway is antiviral to both DENV and ZIKV. Copyright © 2020 American Society for Microbiology.Globally, drug regulators have approved statins for the prevention of cardiovascular disease (CVD), although their use in primary prevention has been controversial. A highly publicised debate has ensued over whether the benefits outweigh the harms. Drug regulators, which are legally required to make independent judgements on drug approvals, have remained silent during the debate. Our aim was to navigate the decision-making processes of European drug regulators and ultimately request the data upon which statins were approved. Our findings revealed a system of fragmented regulation in which many countries licensed statins but did not analyse the data themselves. There is no easily accessible archive containing information about the licensing approval of statins or a central location for holding the trial data. This is an unsustainable model and serves neither the general public, nor researchers. © Author(s) (or their employer(s)) 2020. No commercial re-use. See rights and permissions. Published by BMJ.Breast density has been a critical topic in mammography and women's health for several years. Many states have created laws and mandates to ensure that patients and ordering providers receive information regarding a patient's breast density. Mammographers and patients must understand breast density classifications and how they can affect clinical assessment, diagnosis, and treatment. During an examination, understanding breast density can improve a mammographer's ability to achieve images of diagnostic quality, while ensuring the patient remains as comfortable as possible.