001) and hospital (p < 0.001). The age of children in the UF with miniaturized CPB group was relatively younger (median 1.5 months, IQR 0.3-4.6 months), and the preoperative weight was relatively lower (median 3.9 kg, IQR 3.2-5.4 kg). Moreover, this group of children had a relatively longer postoperative MV time and length of stay in the ICU and hospital.
 
  The miniaturized CPB system could decrease the usage of UF. Good results were achieved in children who did not use UF based on the miniaturized CPB circuit system during congenital heart surgery.
 The miniaturized CPB system could decrease the usage of UF. Good results were achieved in children who did not use UF based on the miniaturized CPB circuit system during congenital heart surgery.SARS CoV-2 is the causative agent of the pandemic disease COVID-19. There is an urgent need for effective drugs or vaccines which can effectively combat this outbreak. The main protease (Mpro), a key component for the SARS CoV-2 replication, is considered to be one of the important drug targets for developing anti-COVID-19 drugs. This SARS CoV-2 Mpro/cysteine protease has high sequence similarity with the same protease from SARS CoV-1. Previously, it has been shown experimentally that eight diterpenoids and four biflavonoids derived from the leaf of Torreya nucifera show inhibitory effect on the cleavage/catalytic activity of the SARS CoV-1 Mpro. But whether these phytochemicals exhibit any inhibitory effect on SARS CoV-2 Mpro is unclear. To understand this fact, here, we have adopted various in-silico approaches. Diterpenoids and biflavonoids those qualified pharmacological test (hinokiol, amentoflavone, bilobetin and ginkgetin) and two well-known Mpro inhibitors (N3 and lopinavir) were subjected for molecular docking studies. Only three biflavonoids (amentoflavone, bilobetin and ginkgetin) were selected by comparing their binding affinities with N3 and lopinavir. They interacted with two most important catalytic residues of Mpro (His41 and Cys145). Molecular dynamics studies further revealed that these three Mpro-biflavonoid complexes are highly stable and share a similar degree of compactness. Besides, these complexes experience less conformational fluctuations and more expansion than Mpro-N3 and/or Mpro-lopinavir complex. MM-GBSA and H-bond analysis further corroborated these findings. Altogether, our study suggested that these three biflavonoids could possibly inhibit the proteolytic/catalytic activity of SARS CoV-2 Mpro and might be useful for COVID-19 treatment. Communicated by Ramaswamy H. Sarma.To determine if student pharmacists' confidence in their knowledge and skills, and their attitudes toward older adults improved throughout pharmacy school with an integrated geriatrics didactic curriculum (years 1-3) and a final year of clinical training including a required advanced pharmacy practice experience (APPE) in geriatrics (year 4). A two-part voluntary anonymous survey was administered at three different time points to two large cohorts of student pharmacists. The first part of the survey assessed students' confidence in attaining geriatrics competencies. The second part of the survey used the UCLA Geriatrics Attitudes Scale to assess students' attitudes. Of the 286 students who were emailed the survey, 236 student pharmacists completed it at the first assessment. Student pharmacists showed an increase in confidence in achieving geriatrics competencies from their first year to their third year, and further increase after their clinical training. Most students also held a generally positive attitude toward older adults from P1 to P4 year. Integration of geriatrics throughout the didactic and experiential curriculum made an impact on student pharmacists' confidence in their competency toward caring for older adults, while maintaining a positive attitude toward older adults throughout pharmacy school.Video analysis is used in sport to derive kinematic variables of interest but often relies on time-consuming tracking operations. The purpose of this study was to determine speed, accuracy and reliability of 2D body landmark digitisation by a neural network (NN), compared with manual digitisation, for the glide phase in swimming. Glide variables including glide factor; instantaneous hip angles, trunk inclines and horizontal velocities were selected as they influence performance and are susceptible to digitisation propagation error. The NN was "trained" on 400 frames of 2D glide video from a sample of eight elite swimmers. Four glide trials of another swimmer were used to test agreement between the NN and a manual operator for body marker position data of the knee, hip and shoulder, and the effect of digitisation on glide variables. The NN digitised body landmarks 233 times faster than the manual operator, with digitising root-mean-square-error of ~4-5 mm. High accuracy and reliability was found between body position and glide variable data between the two methods with relative error ≤5.4% and correlation coefficients >0.95 for all variables. NNs could be applied to greatly reduce the time of kinematic analysis in sports and facilitate rapid feedback of performance measures.Extreme bone resorption due to bone remodelling is one of the reasons for ankle component loosening.  https://www.selleckchem.com/products/Decitabine.html  Finite element (FE) analysis has been effectively used nowadays for pre-clinical analysis of orthopaedic implants. For FE modelling, the selection of bone material and dead zone play a vital role to understand the bone remodelling. This study deals with the effects of different cancellous elastic modulus-density relationships and dead zone on bone remodelling around the tibia owing to total ankle replacement (TAR), using finite element analysis with physiological loading conditions. This study also investigated the bone stimulus distribution in the tibia to identify the initial indication of bone density changes due to bone remodelling. Additionally, the Hoffman failure criterion was used to investigate the chances of implant-bone interface failure due to different cancellous bone material modelling and bone remodelling. The present bone remodelling study consists of three different dead or lazy zones (±0.75, ±0.