ancreas may be an important parameter associated with significant risk factors for clinically relevant postoperative pancreatic fistula after pancreaticoduodenectomy in patients with a nondilated main pancreatic duct. Significant resources are invested in maximizing player performance without extensive knowledge of the athletic progression of elite female soccer players during their career. The aim of the current study was therefore to investigate the change in physical performance characteristics in 12- to 34-year-old female soccer players in a national team program. Mixed-longitudinal study. Physical performance was assessed across five years and 657 testing occasions (n = 143) using anthropometrics, 40 m sprint (10 m split), broad jump, countermovement jump, squat jump, and 30-15 intermittent fitness test (IFT). Using a Gaussian mixture model, Youth and Senior groups were bifurcated at approximately 23 years old. Subsequent linear mixed models for each group and variable identified significant improvements in the Youth group in maximal speed (30-40 m split), broad jump, countermovement jump, and final velocity (p ≤ 0.002), and a decrease in squat jump height with increasing age (p = 0.04). The Senior group recorded slower 10 m sprint time and a decrease in squat jump height with increasing age (p < 0.001). Body mass increased from 12 to 34 years old (Youth and Senior p ≤ 0.001). The Youth group significantly differed in the rate of change compared to the Senior group in body mass, 10 m sprint time, countermovement jump, squat jump, and final velocity (p ≤ 0.001). This information can be used to identify average rates of physical performance improvement and decay to help guide optimal physical training and maximize the longevity of a female soccer players' career. This information can be used to identify average rates of physical performance improvement and decay to help guide optimal physical training and maximize the longevity of a female soccer players' career. The use of anticoagulant medications leads to a higher risk of developing traumatic intracranial hemorrhage (tICH) after a mild traumatic brain injury (mTBI). The management of anticoagulated patients can be difficult to determine when the initial head computed tomography is negative for tICH. There has been limited research on the risk of delayed tICH in patients taking direct oral anticoagulant (DOAC) medications. Our aim was to determine the risk of delayed tICH for patients anticoagulated with DOACs after mTBI. We conducted a systematic review using Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines and searched several medical databases to examine the risk of delayed tICH in patients on DOACs. There were 1252 nonduplicate studies that were identified through an initial database search, 15 of which met our inclusion and exclusion criteria and were included in our analysis after full-text review. A total of 1375 subjects were combined among the 15 studies, with 20 instances of delayed tICH after mTBI. Nineteen of the 20 patients with a delayed tICH were discharged without any neurosurgical intervention, and 1 patient on apixaban died due to a delayed tICH. This systematic review confirms that delayed tICH after mTBI in patients on DOACs is uncommon. However, large, multicenter, prospective studies are needed to confirm the true incidence of clinically significant delayed tICH after DOAC use. Due to the limited data, we recommend using shared decision-making for patients who are candidates for discharge. This systematic review confirms that delayed tICH after mTBI in patients on DOACs is uncommon. https://www.selleckchem.com/products/protac-tubulin-degrader-1.html However, large, multicenter, prospective studies are needed to confirm the true incidence of clinically significant delayed tICH after DOAC use. Due to the limited data, we recommend using shared decision-making for patients who are candidates for discharge.The global spread of COVID-19 has created an urgent need for a safe and effective vaccine. However, in the United States, the politicization of the vaccine approval process, including which public figures are endorsing it, could undermine beliefs about its safety and efficacy and willingness to receive it. Using a pair of randomized survey experiments, we show that announcing approval of a COVID-19 vaccine one week before the presidential election compared to one week after considerably reduces both beliefs about its safety and efficacy and intended uptake. However, endorsement by Dr. Anthony Fauci increases confidence and uptake among all partisan subgroups. Further, an endorsement by Dr. Fauci increased uptake and confidence in safety even if a vaccine receives pre-election approval. The results here suggest that perceptions of political influence in COVID-19 vaccine approval could significantly undermine the viability of a vaccine as a strategy to end the pandemic. Chinese elders are under high threats of seasonal influenza, while showing low influenza vaccination coverage comparing with other countries. The study explored the impacts of free vaccination policy and associated factors on influenza vaccination behavior of the elderly in Zhejiang Province, China, offering a guidance of interventions for protecting elders from seasonal influenza. 1210 elders ≥60years were conveniently recruited between July and September of 2019. 607 of them were sampled from 6 counties with free vaccination policy, while the other 603 elderly people were sampled from another 6 comparable counties without the policy. A self-reported questionnaire, involving socio-democratic information, physical status and behavior, influenza knowledge, vaccination awareness, relatives of healthcare workers, and vaccination behavior, was completed by elders under supports of research assistants. Chi-square tests and logistic regression analyses were performed to explore the impacts of research factors. ts, such as issuing free vaccination policy, enriching influenza knowledge, and guiding positive vaccination awareness for both elders and healthcare professionals are recommended to be included into influenza immunization strategies. Free vaccination policy plays the most fundamental role of improving vaccination coverage among studied factors. To protect elders from seasonal influenza, effective measurements, such as issuing free vaccination policy, enriching influenza knowledge, and guiding positive vaccination awareness for both elders and healthcare professionals are recommended to be included into influenza immunization strategies.