https://www.selleckchem.com/products/elacridar-gf120918.html High Intensity Focused Ultrasound (HIFU) is an emerging non-invasive, targeted treatment of malignancy. The aim of this review was to assess the efficacy, safety and optimal technical parameters of HIFU to treat malignant lesions of the hepatobiliary system. A systematic search of the English literature was performed until March 2020, interrogating Pubmed, Embase and Cochrane Library databases. The following key-words were input in various combinations 'HIFU', 'High intensity focussed ultrasound', 'Hepatobiliary', 'Liver', 'Cancer' and 'Carcinoma'. Extracted content included Application type, Exposure parameters, Patient demographics, and Treatment outcomes. Twenty-four articles reported on the clinical use of HIFU in 940 individuals to treat malignant liver lesions. Twenty-one studies detailed the use of HIFU to treat hepatocellular carcinoma only. Mean tumour size was 5.1cm. Across all studies, HIFU resulted in complete tumour ablation in 55% of patients. Data on technical parameters and the procedurames and explore the risks and benefits of combination therapies. Myopia prevalence has increased in recent years, including the levels of high myopia. While myopia has been associated with scleral remodelling and changes in posterior scleral shape, there has been little research examining how myopia affects in-vivo anterior sclera shape. We compared anterior scleral shape in emmetropes, low to moderate myopes, and high myopes. In this prospective study, the Eye Surface Profiler instrument was used to quantify anterior eye surface shapes of forty-five young adult participants (58 % females) aged between 18 and 35 years, including 15 emmetropes, 15 low to moderate myopes, and 15 high myopes. Sagittal height and axial radius of curvature of regions over the nasal and temporal corneal periphery and anterior sclera were exported and analysed. After quality control of the data, 39 and 43 subjects had data analysed