https://pragmatickr.com/ Pragmatic Free Trial Meta Pragmatic Free Trial Meta is a non-commercial, open data platform and infrastructure that supports research on pragmatic trials. It collects and shares cleaned trial data and ratings using PRECIS-2 allowing for multiple and diverse meta-epidemiological studies that compare treatment effects estimates across trials with different levels of pragmatism as well as other design features. Background Pragmatic trials provide real-world evidence that can be used to make clinical decisions. The term "pragmatic" however, is not used in a consistent manner and its definition and assessment require further clarification. Pragmatic trials should be designed to inform clinical practice and policy decisions, rather than to prove an hypothesis that is based on a clinical or physiological basis. A pragmatic trial should strive to be as close to the real-world clinical environment as is possible, including its participation of participants, setting and design, the delivery and execution of the intervention, and the determination and analysis of the outcomes, and primary analysis. This is a significant distinction from explanatory trials (as described by Schwartz and Lellouch1) which are intended to provide a more thorough confirmation of an idea. The trials that are truly practical should be careful not to blind patients or the clinicians in order to result in bias in the estimation of the effects of treatment. The pragmatic trials also include patients from various healthcare settings to ensure that their results can be generalized to the real world. Additionally, pragmatic trials should focus on outcomes that are crucial to patients, like quality of life or functional recovery. This is particularly important in trials that require the use of invasive procedures or could have harmful adverse impacts. The CRASH trial29, for example, focused on functional outcomes to compare a two-page report with an electronic system to monitor the h