https://www.selleckchem.com/products/mhy1485.html Study of the role of the phenotypic composition of lymphocytes, shifts in which can cause the development of various pathological processes, including sensorineural hearing loss, is an important area of modern research. Purpose of the study. To study the population and subpopulation composition of lymphocytes and their intercellular cooperation in persons with occupational sensorineural hearing loss. Phenotyping of blood lymphocytes (CD3+, CD4+, CD8+, CD9+, CD16+, CD20+, CD21+, CD23+, CD25+, CD95+) was performed by indirect immunofluorescence. Individuals with sensorineural hearing loss were found to have hyperactivation in both T- and B-cell links immunity. The revealed changes indicate a violation of immunoregulation through factors of intercellular cooperation, and the established relationships between populations and subpopulations of lymphocytes indicate increased activity components of the immune system, their important role in the implementation of the immune response in persons with sensorineural hearing loss. The revealed changes indicate a violation of immunoregulation through factors of intercellular cooperation, and the established relationships between populations and subpopulations of lymphocytes indicate increased activity components of the immune system, their important role in the implementation of the immune response in persons with sensorineural hearing loss.PEACH is an important tool for evaluation of children's hearing development, used in age 2-7 years. It is also appropriate for amplification outcomes measurements. PEACH scale includes 13 questions. Parents fill the questionnaire after week observation of child's hearing behavior in different situations. The goal of the study was validation of Russian version of PEACH scale. Translation and cross-cultural adaptation were performed following international guidelines. 50 children with normal hearing and 50 hearing impaired children were involved