OBJECTIVE To examine changes in measures of cardiovascular health in male and female firefighters over 5 years. METHODS Anthropometrics and biomarkers of cardiovascular health from two occupational medical exams separated by 5 years (2009-2016) were examined from a cohort of US career firefighters in Virginia (males, n = 603; females, n = 69). Changes over time were tested using paired t-tests and McNemar's tests. RESULTS At baseline, 29% of males and 10% of females were obese. Body weight and body mass index significantly increased (P  less then  0.05) in males (2.5 ± 0.2 kg) (0.8 ± 0.1 kg/m) and females (2.5 ± 0.8 kg) (1.0 ± 0.3 kg/m) over the 5-year period. The prevalence of obesity, hypercholesterolemia, hypertensive medication usage and high blood glucose significantly increased in males over the 5-year period. CONCLUSIONS While improvements in blood pressure were observed, large percentages of firefighters, particularly males, had CVD risk factors which increased over time.OBJECTIVES There is no pesticide related illness (PRI) surveillance program in Illinois. This study examines the quality of state-based data sources for their ability to inform public health surveillance on PRI. METHODS We estimated the counts of PRI by probabilistic data linkage of hospital discharge, emergency department and poison center databases from 2010-2015. We characterized identified PRI cases. RESULTS We identified 3,867 unique cases of PRI and 6,269 asymptomatic pesticide exposures. Out of the 3,867 PRI cases, there were 1,319 emergency department visits and 321 hospitalizations. We identified 13 deaths and 1,640 major or moderate effects from PRI. Over half of ingestion related exposures occurred in children aged 0-4 years. Workers' compensation and Emergency Medical Service data were unusable. CONCLUSION An effective public health surveillance on PRI requires reliable state data sources and cost-effective methods of assembling data from multiple sources.Invasive fungal infections (IFIs) are an important cause of morbidity and mortality in children with cancer. Studies on the clinical characteristics of IFI in children with solid tumors are limited. This Dutch retrospective cohort study reviewed the medical records of 61 children with solid tumors to analyze the clinical characteristics during their full treatment period. Seven IFI episodes were reported in 6/61 patients (10%), all diagnosed with intermediate-risk or high-risk Wilms tumor or neuroblastoma. Larger studies are necessary to reveal the determinants of IFI in this group of patients and the value of fungal prophylaxis.We report a case of a 2-year-old girl who was diagnosed with natural killer cell acute lymphoblastic leukemia and treated with an acute lymphoblastic leukemia chemotherapy regimen. Two months posttherapy, the disease relapsed with a myeloid immunophenotype. Complete response was then achieved with acute myeloid leukemia therapy followed by unrelated donor umbilical cord allogenic stem cell transplant. Retrospectively, reanalysis of the diagnostic specimen showed minimal myeloperoxidase expression that was called negative by conventional single parameter linear gating but better appreciated on histogram overlays. This case illustrates that even low levels of myeloperoxidase expression should be considered significant in lineage assignment in acute leukemia.Wiskott-Aldrich syndrome (WAS) and osteopetrosis are 2 different, rare hereditary diseases. Here we report clinical and molecular genetics investigations on an infant patient with persistent thrombocytopenia and prolonged fever. He was clinical diagnosed as osteopetrosis according to clinical presentation, radiologic skeletal features, and bone biopsy results.  https://www.selleckchem.com/products/ly333531.html  Gene sequencing demonstrated a de novo homozygous mutation in 5'-untranslated region of TNFRSF11A, c.-45A>G, which is relating to osteopetrosis. Meanwhile, a hemizygous transition mutation in WAS gene, c.400G>A diagnosed the infant with WAS. This is the first clinical report for the diagnosis of osteopetrosis coinheritance with WAS in a single patient.OBJECTIVE The objective of this study was to report the case of a girl diagnosed as suffering from multisystem, BRAF V600E-positive refractory Langerhans cell histiocytosis (LCH) and coexistent Erdheim-Chester disease (ECD) with perirenal, intracranial involvement and the dramatic response to clofarabine treatment. OBSERVATIONS Histiocytoses are rare diseases with a broad clinical spectrum. Recent evidence supports a molecular and clinical overlap between LCH and ECD, and mixed LCH/ECD is now a separate entity. However, only a few pediatric cases of mixed disease have been reported in the literature. CONCLUSIONS In a child with refractory, multisystem histiocytosis and atypical presentations, mixed LCH/ECD should be suspected in the differential diagnosis.BACKGROUND Bloodstream infection (BSI) remains a considerable cause of morbidity and mortality for cancer patients. With a better understanding of it, better methods can be used. The primary objective of this study was to describe the characteristics of BSIs in our institution, and the second was to determine the possible risk factors associated with them. MATERIALS AND METHODS Data of cancer patients from 2009 to 2015 at our institution were included. Medical information and blood cultures were analyzed to determine the BSI rate. The χ and Fisher exact tests were used for categorical data and to determine risk factors associated with BSIs and pathogens. RESULTS A total of 565 (8.6%) events were diagnosed with BSIs. Although gram-negative bacteria (52.6%) were the most commonly isolated pathogens, gram-positive microorganisms (45.0%) were also prevalent. Oral and gastrointestinal organisms were common. Pathogens were more likely to be identified in patients with central venous catheters and in patients with prolonged neutropenia (P less then 0.05). CONCLUSIONS This study provides updated epidemiology in BSIs and helps with the prevention and management of suspected BSIs in vulnerable patients. Better anti-infection therapy could be provided to these patients based on the isolated pathogens.