Our findings could be useful for experimentalists to realize silaaromatics.We fabricate a ferroelectric field effect transistor (FeFET) based on a semiconducting vanadium dioxide (VO2) nanowire (NW), and we investigate its electron transport characteristics modulated by the ferroelectric effects. The transistor consists of a single VO2 NW as the channel and a ferroelectric Pb(Zr0.52Ti0.48)O3 (PZT) thin film as the dielectric gate. The conductance of the VO2 NW channel is found to be feasibly modulated by the ferroelectric gate with an 85% resistance change under the gate voltage of 18 V (at an applied field of about 0.75 MV cm-1). The electron transport property of the device can be controlled by the remnant polarization of the PZT layer due to the nonvolatile property of the ferroelectric gate, with an off-field change of channel resistance up to 50%. Moreover, multiple resistive states can be achieved by sweeping gate voltage across the device appropriately. These results demonstrate that ferroelectric gate modulation is an efficient tool to regulate the electron transport properties of the VO2 NW, and the VO2-NW-FeFET has potential applications in nonvolatile and low-power consumption devices.l-Theanine is an important component found in tea and has positive effects on nutrient absorption and transport. However, whether l-theanine can regulate glucose, lipid, and protein metabolism remains unknown. This study aims to investigate the effects of l-theanine on glucose, lipid, and protein metabolism in male Sprague-Dawley rats and characterize the underlying mechanisms. Compared to the control group, l-theanine increased the contents of hepatic and muscle glycogen, serum total protein (TP), and albumin (Alb), lowered the serum low-density lipoprotein cholesterol (LDL-C) level, decreased the activity of acetyl-CoA carboxylase (ACC), and enhanced carnitine palmitoyl transferase-1 (CPT-1) activity in the liver. Additionally, l-theanine upregulated the mRNA expression of phosphofructokinase (PFKL), CPT-1, insulin receptor (INSR), insulin receptor substrate (IRS), and liver kinase B1 (LKB1) and downregulated the mRNA expression of phosphoenolpyruvate carboxykinase 1 (PCK1), glucose-6-phosphatase catalytic subunit (G6PC), fatty acid synthase (FAS), and 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR). Moreover, l-theanine upregulated the expression of PFKL, glycogen synthase 2 (GYS2), ribosomal protein S6 (S6), INSR, IRS, and phosphatidylinositol-4,5-bisphosphate 3-kinase (PI3K) proteins; downregulated the expression of FAS, sterol regulatory element binding protein-1c (SREBP-1c), and HMGCR proteins; enhanced the phosphorylation of the mammal target of rapamycin (mTOR), ribosomal protein S6 kinase (p70S6K), protein kinase B (AKT), and AMP-activated protein kinase (AMPK); and decreased the phosphorylation of glycogen synthase kinase 3β (GSK-3β) and ACC1. Furthermore, 100 mg kg-1l-theanine was more effective at eliciting these effects than 200 and 400 mg kg-1l-theanine. In conclusion, l-theanine can regulate glucose, lipid, and protein metabolism via insulin and AMPK and their downstream signaling pathways.Cyclocurcumin is a turmeric component that has attracted much less attention compared to the well-known curcumin. In spite of the less deep characterization of its properties, cyclocurcumin has shown promising anticancer effects when used in combination with curcumin. Especially, due to its peculiar molecular structure, cyclocurcumin can be regarded as an almost ideal photoswitch, whose capabilities can also be exploited for relevant biological applications. Here, by means of state-of-the-art computational methods for electronic excited-state calculations (TD-DFT, MS-CASPT2, and XMS-CASPT2), we analyze in detail the absorption and photoisomerization pathways leading from the more stable trans isomer to the cis one. The different molecular surroundings, taken into account by means of the electrostatic solvent effect and compared with available experimental data, have been found to be critical in describing the fate of irradiated cyclocurcumin when in non-polar environments, an excited state barrier prevents photoisomerization and favours fluorescence, whereas in polar solvents, an almost barrierless path results in a striking decrease of fluorescence, opening the way toward a crossing region with the ground state and thus funneling the photoproduction of the cis isomer.Benziporphyrins are versatile macrocycles exhibiting aromaticity switching behaviors. The existence of both Hückel and Möbius (anti)aromaticity has been reported in these systems, whose validity is respectively governed by the [4n + 2] and [4n] π-electron rule on the macrocyclic pathway. Despite the experimental evidence on the floppiness of benziporphyrins, the switching mechanism between Hückel and Möbius structures is still not clear, as well as the factors influencing the stability of the different π-conjugation topologies.  https://www.selleckchem.com/products/AZD0530.html  For these reasons, we performed a systematic study on A,D-di-p-benzihexaphyrins(1.1.1.1.1.1) with two redox states corresponding to [28] and [30] π-electron conjugation pathways. Whereas benzi[28]hexaphyrin obeys Möbius aromaticity, benzi[30]hexaphyrin follows Hückel aromaticity. The dynamic interconversion between Möbius and Hückel aromaticity is investigated through the rotation of a phenylene ring, which acts as the topology selector. Further analyses of the energy profiles using energy decomposition and information-theoretic approaches provide new insights into conformational stability, aromaticity and antiaromaticity for these species. Strong and opposite cross correlations between aromaticity indexes and information-theoretic quantities were found for the two macrocyclic systems with opposite global aromaticity and antiaromaticity behaviors. These results indicate that Hückel and Möbius aromaticity and antiaromaticity, though qualitatively different, are closely related and can be interchanged, and information-theoretic quantities provide a novel understanding about their relevance. Our present results should provide in-depth insights to appreciate the nature and origin about Möbius (anti)aromaticity and its close relationship with Hückel (anti)aromaticity.