https://www.selleckchem.com/products/paquinimod.html 4 mm. The differences in the absolute integral depth dose curves (IDDs) between the BP84 and BP150 ranged from 0.3% to 1.0% for the spot sizes and beam energies tested. As predicted by the Monte Carlo modeling, the greatest differences were found in the plateau region of the IDDs. Also, the IDDs measured with the BP150 were very similar to those of the ideal 40 cm diameter detector Monte Carlo simulations. CONCLUSIONS We conclude that the BP150 offers a small, but a useful reduction in uncertainty from the nuclear halo effect for the system under test. This article is protected by copyright. All rights reserved.PURPOSE To introduce the definite target volume (DTV) and evaluate dosimetric consequences of boosting dose to this region of high CTV- and low OAR- probability. METHODS This work defines the DTV via occupancy probability and via contraction of the CTV by margin M less any PRV volumes. The equivalence to within varying occupancy probability of the two methods is established for spherical target volumes. We estimate a margin for four radiation treatment sites based on modern IGRT-literature utilizing repeat volumetric imaging. Based on margins and patient-specific DTV targets, the ability to dose-escalate the DTV including the effects of spatial uncertainty was evaluated. We simulate delivery assuming violation of the underlying spatial uncertainty of 130%. RESULTS Contracting the PTV by M and excluding PRV volumes, the DTV ranged from 7.3 cc - 93.6 cc. In a brain treatment, DTV-Dmax increased to 66.8 Gy (145% of prescription isodose); in advanced lung DTV-Dmax increased to 122.2 Gy (204% of prescription isodose), in a pancreatic case DTV-Dmax was boosted up to 87.3 Gy (173% or prescription isodose), and in retroperitoneal sarcoma to 74.6 Gy (249% of prescription isodose). The high point doses were not associated with increased dose to OARs, even when considering the effects of spatial uncertainty. Simulated