https://www.selleckchem.com/products/ldc195943-imt1.html The permeability of fluorescein-5-isothiocyanate-dextran or periodontal pathogen was significantly increased by NE treatment in the human gingival epithelial monolayer. These findings suggest that NE induces the disruption of the gingival epithelial barrier and bacterial invasion in periodontal tissues, aggravating periodontitis. Vancomycin is widely used in neonatal sepsis but proportion of newborn reaching recommended concentration is variable. Fluid status impact on vancomycin level remains understudied. We aimed to study fluid factors impacting vancomycin concentration at 24h of treatment. We performed a prospective and retrospective observational monocentric study of NICU patients requiring a vancomycin treatment. We used a continuous infusion protocol, with age-appropriate loading and maintenance doses. Vancomycin target serum concentration after 24h (C ) was above 20mg/L. Demographic, infections, and organ failure variables were analyzed as potential predictors of C . Over the study period, 70 infective episodes in 52 patients were included. At treatment initiation, the median post-natal age was 12.5days (IQR 7-23), post menstrual age 30weeks (IQR 28-35), and median weight 1140g (IQR 835-1722). Germs isolated were mainly gram-positive with 73.5% being coagulase-negative Staphylococci. Median C was 18.7mg/L (IQR 15.4-22.4)ted with low vancomycin concentration presence of systemic inflammation and weight gain. • Proportion of patients with adequate vancomycin concentration using a target adapted to nosocomial gram-positive bacteria MIC is low. • We confirmed the role of creatinine level and report two new factors associated with low vancomycin concentration presence of systemic inflammation and weight gain.Cognitive frailty (CF) is a clinical condition defined by the presence of both mild cognitive impairment (MCI) and physical frailty (PF). Elderly with CF are at greater risk of dementia than those with