Introduction Among the most critical health systems components that requires strengthening to improve maternal, newborn and child health (MNCH) outcomes in Nigeria is the concept of equity. UNICEF has designed the equitable impact sensitive tool (EQUIST) to enable policymakers improve equity in MNCH and reduce disparities between the most marginalized mothers and young children and the better-off. Methods Using the latest available DHS data sets, we conducted EQUIST situation and scenario analysis of MNCH outcomes in Nigeria by sub-national categorization, wealth and by residence. We then identified the intervention package, the bottlenecks and strategies to address them and the number of deaths avertible. Results EQUIST profile analysis showed that the number of under-five deaths was considerably higher among the poorest and rural population in Nigeria, and was highest in North-West region. Neonatal causes, malaria, pneumonia and diarrhoea were responsible for most of the under-five deaths. Highest maternal mortality was recorded in the North-West Nigeria. Ante-partum, intrapartum and postpartum haemorrhages and hypertensive disorder, were responsible for highest maternal deaths. EQUIST scenario analysis showed that an intervention package of insecticide treated net can avert more than 20,000 under-five deaths and delivery by skilled professionals can avert nearly 17,000 under-five deaths. While as many as 3,370 maternal deaths can be averted by deployment of skilled professionals. Conclusion Scaling up integrated packages of essential interventions across the continuum of care, addressing the human resource shortages in rural area and economic/social empowerment of women are policy recommendations that can improve MNCH outcomes in Nigeria. © Chigozie Jesse Uneke et al.Introduction Tetralogy of Fallot (TOF) is one of the most common cyanogenic congenital heart defects. It represents 10% of congenital heart diseases in children. Coronary artery anomalies (CAA) have been reported in 2% to 14% of cases in patients with TOF, according to angiographic, surgical and autopsy series. Many of these anomalies are difficult to detect during surgery. The objective of this article is to study the prevalence of the coronary artery anomalies in patients with TOF as well as their surgical management in our hospital between 2007 and 2015. Methods A retrospective study was conducted on 90 patients with TOF aged 1 month to 10 years who were operated on in the Department of Paediatric Cardiac Surgery of Cheikh Zaid Hospital between 2007 and 2015. None of the patients had preoperative coronary angiography and all the anomalies were diagnosed during surgery. Patient clinical data were collected from patient records and from the hospital information system. The qualitative variables are expressedficulty of diagnosing them pre-operatively. The management of these anomalies is mainly surgical and the technique used by our team is proved to be safe and effective. © Mohamed Rida Ajaja et al.Introduction Malaria is a major public health problem, responsible for many complications during pregnancy including inadequate intra-uterine growth and hypotrophies. The aim of this study was to determine the adherence to the 3 doses of sulfadoxine-pyrimethamine-based intermittent preventive treatment (IPT) on birthweight in the Cotonou health zone II and III. Methods We conducted a cross-sectional study focusing on 630 women in the postpartum period residing in the Cotonou health zone II and III and selected using a two stage sample.  https://www.selleckchem.com/products/protosappanin-b.html  Data were collected through a questionnaire and a data processing form. For analysis, data were weighted and we used variance analysis to compare means and to compare proportions with Chi-square Test including estimates regarding the strength of the association by odds ratio (OR) and confidence interval at 95%. Results Adherence to the 3 doses of sulfadoxine-pyrimethamine-based intermittent preventive treatment was 34.08% (CI95% 24.84% 43.30%]. A significant birthweight-gain of 264.5 g (p less then 0.001) in mothers who had received more than 3 doses of sulfadoxine-pyrimethamine-based intermittent preventive treatment and chances of having low birth weight baby was lower (OR = 0.45; p = 0.001) among these mothers compared to those who had received less than 3 doses of sulfadoxine pyrimethamine. Conclusion This study highlights low adherence to the new 3-dose regimen of sulfadoxine-pyrimethamine-based intermittent preventive treatment in the Cotonou health zone II and III, but it reflects its potential to contribute to the reduction of the risk of low birth weight. Strategies must therefore be implemented to strengthen its application for prevention of malaria and of its consequences on vulnerable targets. © Chabi Olaniran Alphonse Biaou et al.Ablative treatment for hepatocellular carcinoma is standard of care in selected settings and is endorsed by international societal guidelines. Centrally located hepatocellular carcinoma are difficult to treat due to their proximity to vasculature and central bile ducts. Irreversible electroporation is a nonthermal ablation modality that has been shown to preserve the extracellular matrix and is less likely to damage structures such as bile ducts and is not susceptible to vascular heat sink. Successful irreversible electroporation requires the parallel placement of probes which can be prevented by ribs or the sternum. This case report describes the use of the coaxial bone biopsy system to enable transchondral access and facilitate parallel placement of probes during irreversible electroporation IRE for the treatment of hepatocellular carcinoma. © 2020 The Authors. Published by Elsevier Inc. on behalf of University of Washington.Epidural lipomatosis with associated syrinx formation is an exceedingly rare clinical entity. In this case report we present a 48-year old female who initially presented with symptoms of progressive myelopathy and later developed urinary incontinence. Her imaging studies showed upper thoracic epidural lipomatosis and associated spinal stenosis, cord compression and a mildly expansile right paracentral syrinx at C7-T1. She underwent a decompression surgery which provided her with partial symptomatic relief. On MRI, there was a mild decrease in the size of syrinx and some improvement in the degree of spinal stenosis. However, the subsequent clinical improvement supported the possibility that spinal compression caused by epidural lipomatosis could have resulted in syrinx formation. Therefore, such cases can be appropriately treated with spinal decompression surgeries or syrinx shunting procedures. © 2020 The Authors. Published by Elsevier Inc. on behalf of University of Washington.