https://www.selleckchem.com/products/TG100-115.html Elevated levels of periostin (Postn) in the cartilage and bone are associated with osteoarthritis (OA). However, it remains unknown whether Postn loss-of-function can delay or prevent the development of OA. In this study, we sought tobetter understand the role of Postn in OA development and assessed the functional impact of Postn deficiency on post-traumatic and age-related OA in mice. The effects of Postn deficiency were studied in two murine experimental OA models using Postn (n= 32) and littermate wild-type (wt) mice (n= 36). Post-traumatic OA was induced by destabilization of the medial meniscus (DMM) in 10-week-old mice (n= 20); age-related OA was analyzed in 24-month-old mice (n= 13). Cartilage degeneration was assessed histologically using the OARSI scoring system, and synovitis was evaluated by measuring the synovial lining cell layer and the cells density in the synovial stroma. Bone changes were measured by μCT analysis. Serum levels of Postn were determined by ELISA. Expression of Postn and csion and cell-differentiation processes were enriched in Postn mice, while those related to cell-cycle and DNA-repair were enriched in wt mice. Postn deficiency protects against DMM-induced post-traumatic and age-related spontaneous OA. RNA-seq findings warrant further investigations tobetter understand the mechanistic role of Postn and its potential as a therapeutic target in OA. Postn deficiency protects against DMM-induced post-traumatic and age-related spontaneous OA. RNA-seq findings warrant further investigations to better understand the mechanistic role of Postn and its potential as a therapeutic target in OA. We compared the measured resection (MR) technique and the gap balancing (GB) technique in patients with knee osteoarthritis after primary total knee arthroplasty (TKA) in China to understand the effects of the two techniques on knee function and squat function. From March 2017 to September 2019, a prospe