https://www.selleckchem.com/products/l-mimosine.html 39, 95% CI 1.53-12.67) and medical comorbidity (OR=1.69, 95% CI 1.00-2.86). The depression risk is associated with a history of depressive disorder and medical comorbidity in patients with AS and COPD. Medical history is the leading risk factor for depression during confinement. It is recommended to carry out studies with many participants and study other variables that may mediate said associations during confinement by SAR-CoV-2 in the Colombian Caribbean. The depression risk is associated with a history of depressive disorder and medical comorbidity in patients with AS and COPD. Medical history is the leading risk factor for depression during confinement. It is recommended to carry out studies with many participants and study other variables that may mediate said associations during confinement by SAR-CoV-2 in the Colombian Caribbean. There are reports from countries and in the scientific literature that COVID-19 affect also mental health worldwide. The aim of this study was to understand the level of depression as a result of the COVID-19 situation and possible associations with sociodemographic variables. It's a cross-sectional study. The participants were 155 respondents recruited online in the period 27.04.2020 until 05.06.2020, who completed the Albanian version of PHQ-9. Mean score of depression resulted 10.94 (SD=9.22). 63% of participants agreed that the situation has worsened their psychological state; 35.6% had a mild to severe form of depression and 18.7% had minimal symptoms. 13.4% of participants saw iCBT as helpful, 16.8% a little while 65.8% wanted to try it. Significantly higher depression resulted for females and age-group 18 to 24 years. No significant differences by levels of education, marital status, employment, socio-economic status and by expectations regarding iCBT. Gender and perception of worsened psychological state showed predictive abilities for depression. The situation with Covid-