https://www.selleckchem.com/products/sch-900776.html ion of RASSF1A were 17.20 and 42.13 months for patients without promoter region hypermethylation of RASSF1A and the patients with KRAS mutation with or without hypermethylation of the promoter region of RASSF1A a tumor suppressor gene had poorer survival compared with those patients with wild type KRAS gene, with or without hypermethylation of RASSF1A promoter region. These differences were statistically significant based on Log-rank (Mantel-cox) test (P = 0.0001). The median survivals among patients with mutation in KRAS protooncogene were 16 months and 42 months for NSCLC patients with wild type KRAS gene. Conclusions The aberrant RASSF1A gene promoter methylation with the subsequent mutation in KRAS gene (exon 2) plays a significant role in the pathogenesis and disease progression of non-small cell lung carcinoma (NSCLC). © 2020 Published by Elsevier Ltd.Advanced visible infrared imaging spectrometer-new generation (AVIRIS-NG) airborne Hyperspectral data has 5nm spectral resolution which allows us to identify characteristic spectral signatures of the different altered and weathered mineral assemblage. In this study Airborne AVIRIS-NG hyperspectral data were used to identify the different altered, weathered and clay group of minerals in the Jahajpur, Bhilwara, India. In the study area, different hydrothermal minerals such as Montmorillonite, Smectite and Talc were identified. Apart from this, Goethite/Limonite mineral spectral signatures were identified using the AVIRIS-NG data in the VNIR (visible and near infrared) region of the electromagnetic spectrum. Minerals thus identified were verified by the conventional geological analysis viz. petrography and XRD of the field samples collected from the study area. The results of the conventional geological methods and spectroscopy were in good confirmation with the results found through the analysis of the AVIRIS-NG data. Identified minerals show a good indication of