https://www.selleckchem.com/products/oleic-acid.html 23 ± 24.52］ vs ［78.74 ± 61.25］ ×10⁶/ml, P less then 0.01), the percentage of progressively mobile sperm (［18.71 ± 15.19］% vs ［39.36 ± 9.75］%, P less then 0.01), and the level of FSH (［16.09 ± 17.31］ vs ［4.56 ± 2.41］ IU/L, P less then 0.01), but not between the genotypes and male infertility, and no correlation was found in subgroup analysis. CONCLUSIONS The single nucleotide polymorphisms rs995030 and rs4474514 of the KITLG gene were not significantly correlated with male infertility, which is to be further verified by more studies with samples of larger size and expanded selection range.Objective To investigate the effects of low-dose PDE5 inhibitors on metabolic parameters and erectile function in ED patients with subclinical metabolic syndrome (SCMS). METHODS Totally, 132 ED patients, aged 21－61 (mean 34.5) years, were treated in the Andrology Clinic of the First Hospital of Wenzhou Medical University from April 2017 to May 2018. According to the diagnostic criteria, we divided the patients into groups A (simple ED, n = 40), B (ED with SCMS, n = 34) and C (ED with MS, n = 58) to receive 3 months of oral administration of tadalafil at 5 mg qd at bedtime, and followed them up for 3 months after drug withdrawal. During the treatment, we advised the patients to keep a healthy diet, change bad habits, participate in regular physical exercise, and maintain psychological balance. Before and right after medication and at 3 months after drug withdrawal, we recorded the changes in the IIEF-5 scores, abdominal circumference, blood pressure and levels of fasting blood sugar (FBS), triglyceride (TG) and high-density lipoprotein (HDL) of the patients. RESULTS The IIEF-5 scores showed statistically significant differences at different time points between groups A and C (P 0.05). CONCLUSIONS Periodic administration of low-dose sustained-release PDE5 inhibitors with health education and lifestyle guidance may reverse ED with SC