https://www.selleckchem.com/products/ABT-263.html OBJECTIVE Somatization and functional somatic symptoms reflect conditions in which physical symptoms are not sufficiently explained by medical conditions. Literature suggests that these somatic symptoms may be related to illness exposure in the family. Children with a parent or sibling with a chronic illness may be particularly vulnerable to developing somatic symptoms. This study provides a systematic review of the literature on somatic symptoms in children with a chronically ill family member. METHODS A systematic review (PROSPERO registry IDCRD42018092344) was conducted using six databases (PubMed, EMBASE, PsychINFO, Scopus, CINAHL, and Cochrane) from articles published prior to April 5, 2018. All authors evaluated articles by title and abstract, and then by full-text review. Relevant data were extracted by the first author and reviewed by remaining authors. RESULTS Twenty-seven unique studies met criteria. Seventeen examined somatic symptoms in children with a chronically ill parent and seven evaluated somatic symptoms in children with a chronically ill sibling. Three studies examined somatic symptoms in children with an unspecified ill relative. The strongest relationship between child somatization and familial illness was found with children with a chronically ill parent (13 out of 17 studies). Evidence for somatic symptoms in children with an ill sibling was mixed (4 out of 7 studies found a positive association). CONCLUSIONS The literature on somatic symptoms in children suggest parental illness is related to increased somatic symptoms in children. Research examining the effects of having a sibling with an illness on somatic symptoms is mixed. Several areas of future research are outlined to further clarify the relationship between familial chronic illness and somatic symptoms.OBJECTIVE Most of the research on vasovagal reactions has focused on the contributions of cardiovascular activity to the development o