CTRN 12619001703190 . Registered 04 December 2019.
  An ongoing outbreak of a novel coronavirus (2019-nCoV) pneumonia continues to affect the whole world including major countries such as China, USA, Italy, France and the United Kingdom. We present outcome ('recovered', 'isolated' or 'death') risk estimates of 2019-nCoV over 'early' datasets. A major consideration is the likelihood of death for patients with 2019-nCoV.
 
  Accounting for the impact of the variations in the reporting rate of 2019-nCoV, we used machine learning techniques (AdaBoost, bagging, extra-trees, decision trees and k-nearest neighbour classifiers) on two 2019-nCoV datasets obtained from Kaggle on March 30, 2020. We used 'country', 'age' and 'gender' as features to predict outcome for both datasets. We included the patient's 'disease' history (only present in the second dataset) to predict the outcome for the second dataset.
 
  The use of a patient's 'disease' history improves the prediction of 'death' by more than sevenfold. The models ignoring a patent's 'disease' history performed poorly in test predictions.
 
  Our findings indicate the potential of using a patient's 'disease' history as part of the feature set in machine learning techniques to improve 2019-nCoV predictions. This development can have a positive effect on predictive patient treatment and can result in easing currently overburdened healthcare systems worldwide, especially with the increasing prevalence of second and third wave re-infections in some countries.
 Our findings indicate the potential of using a patient's 'disease' history as part of the feature set in machine learning techniques to improve 2019-nCoV predictions. This development can have a positive effect on predictive patient treatment and can result in easing currently overburdened healthcare systems worldwide, especially with the increasing prevalence of second and third wave re-infections in some countries.
  Neuropathic pain is characterized by spontaneous painful symptoms. Medical therapies include the use of a capsaicin 8% patch (Qutenza®, Grünenthal Gmbh, Germany), and patients may experience a sharp burning sensation at application and removal of the patch. This study aimed to evaluate the impact of playing a standardized hypnosis recording during application, on the pain and anxiety induced by capsaicin treatment.
 
  In a randomized, controlled trial, we assessed the benefits of the intervention firstly on pain and secondly on anxiety, as measured using numerical rating scales. All patients had application of the capsaicin patch, including the possibility for the patient to apply a cold patch. Participants were randomly assigned to one of 3 groups, namely the "Standard group" (no intervention), "Hypnosis group", in which a standardized hypnotic message was played during application, or the "Music group" in which relaxing music was played during application of the patch.
 
  Sixty-nine patients were included. Overall, there was no significant difference in pain scores between groups (p= 0.355). Compared to standard application, anxiety was significantly lower in the hypnosis group after application (p= 0.007), with no significant difference between the standard and music arms (p= 0.271), or between the hypnosis and music arms (p= 0.423).
 
  Listening to a standardized hypnotic message during application of a capsaicin patch was found to significantly lower anxiety. These findings indicate that the use of a hypnotic message can reduce discomfort and warrant its evaluation in other indications of pain or anxiety during treatment procedures.
 
  NCT02822625 .
 NCT02822625 .
  Assessment of the genetic diversity of Plasmodium falciparum parasites from various malaria transmission settings could help to define tailored local strategies for malaria control and elimination. Such assessments are currently scarce in Madagascar.  https://www.selleckchem.com/products/alkbh5-inhibitor-2.html  The study presented here aimed to bridge this gap by investigating the genetic diversity of P. falciparum populations in three epidemiological strata (Equatorial, Tropical and Fringes) in Madagascar.
 
  Two-hundred and sixty-six P. falciparum isolates were obtained from patients with uncomplicated malaria enrolled in clinical drug efficacy studies conducted at health centres in Tsaratanana (Equatorial stratum), Antanimbary (Tropical stratum) and Anjoma Ramartina (Fringes) in 2013 and 2016. Parasite DNA was extracted from blood samples collected before anti-malarial treatment. Plasmodium species were identified by nested PCR targeting the 18S rRNA gene. The genetic profiles of P. falciparum parasites were defined by allele-specific nested PCR on the polymorphic rar, and valuable baseline data for further evaluation of the impact of the control measures implemented in Madagascar.
  In the Greater Mekong Subregion (GMS), current malaria surveillance strategies rely on a network of village health volunteers (VHVs) reporting the results of rapid diagnostic tests (RDTs), known to miss many asymptomatic infections. Integration of more sensitive diagnostic molecular and serological measures into the VHV network may improve surveillance of residual malaria transmission in hard-to-reach areas in the region and inform targeted interventions and elimination responses. However, data on residual malaria transmission that would be captured by these measures in the VHV-led testing and treatment surveillance network in the GMS is unknown.
 
  A total of 114 VHVs were trained to collect dried blood spots from villagers undergoing routine RDTs as part of VHV-led active and passive case detection from April 2015 to June 2016. Samples were subjected to molecular testing (quantitative polymerase chain reaction [qPCR]) to determine Plasmodium falciparum and P. vivax infection and serological testing (againssurveillance by advancing the integration of molecular and serological techniques, through centralised testing approaches or novel point-of-contact tests, will advance progress, and tracking, towards malaria elimination goals in the GMS.
  Previous research shows that many cancer-bereaved youths report unresolved grief several years after the death of a parent. Grief work hypothesis suggests that, in order to heal, the bereaved needs to process the pain of grief in some way. This study explored acute grief experiences and reactions in the first 6 months post-loss among cancer-bereaved teenagers. We further explored long-term grief resolution and potential predictors of having had "an okay way to grieve" in the first months post-loss.
 
  We used a population-based nationwide, study-specific survey to investigate acute and long-term grief experiences in 622 (73% response rate) bereaved young adults (age > 18) who, 6-9 years earlier, at ages 13-16 years, had lost a parent to cancer. Associations were assessed using bivariable and multivariable logistic regression.
 
  Fifty-seven per cent of the participants reported that they did not have a way to grieve that felt okay during the first 6 months after the death of their parent. This was associated with increased risk for long-term unresolved grief (odds ratio (OR) 4.