Angiogenesis is the physiological process of new blood vessel formation from existing capillary vessels or posterior capillary veins. Its dysfunction could result in a number of diseases, such as cardiovascular diseases and cancer, contributing to death and disability worldwide. Circular RNAs (circRNAs) are a class of novel identified RNA molecules with a special covalent loop structure without a 5' cap and 3' tail, which can lead to novel back-splicing or skipping events from precursor mRNAs. Accumulating evidence suggests that circRNA play critical roles in diseases; in particular, they are abundantly and abnormally expressed in angiogenesis-related diseases. In this review, we describe the role of circRNA under pathological conditions, discuss the association between circRNA and angiogenesis, classify the regulatory mechanisms and suggest that circRNA can be used as potential therapeutic targets for angiogenesis-related diseases under clinical evaluation. Protein-RNA interactions regulate all aspects of RNA metabolism and are crucial to the function of catalytic ribonucleoproteins. Until recently, the available technologies to capture RNA-bound proteins have been biased toward poly(A) RNA-binding proteins (RBPs) or involve molecular labeling, limiting their application. With the advent of organic-aqueous phase separation-based methods, we now have technologies that efficiently enrich the complete suite of RBPs and enable quantification of RBP dynamics. These flexible approaches to study RBPs and their bound RNA open up new research avenues for systems-level interrogation of protein-RNA interactions. The simultaneously efficient removal of cationic and anionic radionuclides is an important and challenging topic for nuclear waste remediation as well as environmental protection. Herein, monoclinic ZIF-8 nanosheets modified with ethyleneimine polymer (denoted as ZIF-8/PEI) was achieved and used to determine the capture behaviors of both U(VI) oxycations and Re(VII) oxyanions from aqueous solution. ZIF-8/PEI assemblies showed a maximum U(VI) and Re(VII) uptake capacity of 665.3 (pH 5.0) and 358.2 mg/g (pH 3.5), respectively. Experimental, spectroscopic and theoretical calculation results directly unraveled that U(VI) adsorption onto ZIF-8/PEI assemblies was mainly ascribed to the coordination with abundant amino groups and weakly due to the Zn terminal hydroxyl groups, while anion exchange mechanism contributed predominantly to the Re(VII) sequestration. This work not only sheds light on the interaction mechanisms of simultaneous capture of U(VI) and Re(VII) but also highlights the versatile material design of cationic and anionic radionuclide immobilization in radioactive wastewater remediation. Diet is the leading predictor of health status, including all-cause mortality, in the modern world, yet is rarely measured; whereas virtually every adult in a developed country knows their approximate blood pressure, hardly any knows their objective diet quality. Leading authorities have called for the inclusion of nutrition in every electronic health record as one of the many remedial steps required to give dietary quality the routine attention it warrants. Existing tools to capture dietary intake are based on either real-time journaling or recall. Journaling, or logging, is time and labor intensive. Recall is notoriously unreliable, as humans are notably bad at remembering detail. Even allowing for the challenge of recall, these dietary intake methods are labor and time intensive, and require analysis at the n-of-1 level. We hypothesize that dietary intake assessment can be "reverse engineered"-predicating assessment on the recognition of fully formed dietary patterns-rather than endeavoring to assemble such a representation one food, meal, dish, or day at a time. This pattern recognition-based method offers potential advantages over existing methods, including speed, efficiency, cost, and applicability. We have developed and provisionally tested such a system, and the results thus far support our hypothesis. We are convinced that leveraging pattern recognition to make dietary assessment quick, user-friendly, economical, and scalable can allow for the conversion of dietary quality into a universally measured and routinely managed vital sign. In this paper, we present the supporting case. A clear understanding of the normal anatomy of the glanular urethra is essential for anatomical reconstruction of the male urethra. In hypospadias surgery, tubularization of the neourethra over a catheter or stent has been the standard method for decades. However, the male urethra is not a tubular structure with uniform configuration and diameter by forming a fossa (navicularis) in the glans penis. We recently investigated the structural anatomy of the glanular urethra using magnetic resonance imaging (MRI). We have shown that the male urethra does not have a uniform tubular structure and not covered by the corpus spongiosum to the end. The glanular urethra that forms the "fossa navicularis" has a wider caliber than the proximal urethra. Its vertical elliptical shape resembles a laterally compressed slit-like passage. The fossa navicularis is covered by a thin layer of fibrous tissue ("septum glandis") which is an extension of tunica albuginea of the corpus cavernosum and the corpus spongiosum.  https://www.selleckchem.com/products/OSI027.html  Our hypothesis account for successful functional reconstruction of hypospadias. In this work, we have developed a novel series of multi-target-directed ligands to address low levels of acetylcholine (ACh), oxidative stress, metal ion dysregulation, and the misfolded proteins. Novel apigenin-donepezil derivatives, naringenin-donepezil derivatives, genistein-donepezil derivatives and chalcone-donepezil derivatives have been synthesized, in vitro results showed that TM-4 was a reversible and potent huAChE (IC50 = 0.36 μM) and huBChE (IC50 = 15.3 μM) inhibitor, and showed potent antioxidant activity (ORAC = 1.2 eq). TM-4 could significantly inhibit self-induced Aβ1-42 aggregation (IC50 = 3.7 μM). TM-4 was also an ideal neuroprotectant, potential metal chelation agent, and it could inhibit and disaggregate huAChE-induced and Cu2+-induced Aβ aggregation. Moreover, TM-4 could activate UPS degradation pathway in HT22 cells and induce autophagy on U87 cells to clear abnormal proteins associated with AD. More importantly, TM-4 could cross BBB in vitro assay. In addition, in vivo assay revealed that TM-4 exhibited remarkable dyskinesia recovery rate and response efficiency on AlCl3-induced zebrafish AD model, and TM-4 indicated surprising protective effect on Aβ1-40-induced vascular injury.