Carrier-free nanodrugs composed of photosensitizers and chemotherapeutic drugs show great potential in synergistic photothermal-chemotherapy. However, the targeting specificity to tumor cells is still a major obstacle for carrier-free nanodrugs. Meanwhile, almost all exogenous tumor-targeting ligands show no therapeutic effect by themselves. Here, a tumor microenvironment-driven self-targeting supramolecular nanodrug was successfully constructed via an indocyanine green (ICG)-templated small-molecule self-assembly strategy with methotrexate (MTX, folic acid-like antitumor drug) followed by post-insertion of weak acidity-responsive PEG for synergistic photothermal-chemotherapy.  https://www.selleckchem.com/products/gyy4137.html  Interestingly, the size and morphology could be adjusted by changing the ICG-to-MTX ratio. Notably, the dynamic introduction of PEG not only could temporarily shield self-targeting function in blood to prolong the circulation time, but also could trigger the activation of self-targeting via re-exposing MTX ligands within the tumor microenvironment to enhance cellular uptake. Furthermore, the dePEGylated nanodrug would be disassembled to release MTX on-demand for chemotherapy via both stimuli of stronger lysosomal acidity and an external NIR laser. Moreover, the elimination of tumors could be realized through NIR-II fluorescence/PA imaging-guided synergistic photothermal-chemotherapy. The tumor microenvironment-driven carrier-free nanodrug based on self-targeting activation via ICG-templated assembly might provide a brand-new idea for synergistic photothermal-chemotherapy.Arsenoplatin-1 (AP-1) is an innovative dual-action anticancer agent that contains a platinum(ii) center coordinated to an arsenous acid moiety. We found that AP-1 spontaneously aggregates in aqueous solutions generating oligomeric species of increasing length. Afterward, we succeeded in solving the crystal structure of the adduct formed between the model protein lysozyme and an early AP-1 oligomer that turned out to be a trimer. Remarkably, this crystal structure traps an early stage of AP-1 aggregation offering detailed insight into the molecular process of the oligomer's growth.A heterogeneous structure formed by coupling two or more phases can reinforce the activity of active sites and expedite electron transfer, which is conducive to boosting its electrocatalytic activity. Herein, we designed nickel foam supported (NiCo2)Se@Ni(OH)2 (NCS@NH) heterojunction nanosheets by a two-step method. First of all, the NiCo2S4@Ni(OH)2 (NiCo2S4@NH) nanosheets coated on nickel foam were acquired via a hydrothermal method. In the selenization treatment that followed, NiCo2S4@NH was converted into NCS@NH heterogeneous nanosheets in which the selenide nanoparticles decorated on the surface of the Ni(OH)2 nanosheets formed heterojunction interfaces, and the heterogeneous structure could accelerate electron transfer, thus improving the catalytic activity. The Ni(OH)2 nanosheets can adequately contact the electrolyte and promote the decomposition of water. Meanwhile, the thickness of the Ni(OH)2 nanosheets gradually decreases with the increase of Co doping (1.5-2.5 mmol), consequently affecting the HER properties. Notably, when the amount of Co salt added is 2 mmol, NCS@NH exhibited superior HER properties (with a voltage of 253 mV at 100 mA cm-2) and excellent stability for 24 h.Neuromorphic computing is of great interest among researchers interested in overcoming the von Neumann computing bottleneck. A synaptic device, one of the key components to realize a neuromorphic system, has a weight that indicates the strength of the connection between two neurons, and updating this weight must have linear and symmetric characteristics. Especially, a transistor-type device has a gate terminal, separating the processes of reading and updating the conductivity, used as a synaptic weight to prevent sneak path current issues during synaptic operations. In this study, we fabricate a top-gated flash memory device based on two-dimensional (2D) materials, MoS2 and graphene, as a channel and a floating gate, respectively, and Al2O3 and HfO2 to increase the tunneling efficiency. We demonstrate the linear weight updates and repeatable characteristics of applying negative/positive pulses, and also emulate spike timing-dependent plasticity (STDP), one of the learning rules in a spiking neural network (SNN).Two derivatives of phenylpyridyl-fused boroles were prepared via functionalization of the pyridyl groups, namely to an electron-rich dihydropyridine moiety (compound 1) and an electron-deficient N-methylpyridinium cation (compound 2). Due to strong conjugation between the dihydropyridine moiety and the boron atom, the reduction potential of compound 1 shifts cathodically. In contrast, compound 2 exhibits three reduction processes with a first reversible reduction potential anodically shifted in comparison to its precursor (TipPBB2) or the non-borylated framework 1-methyl-2-phenylpyridin-1-ium triflate (3). The significantly anodically shifted reduction potential indicates the extreme electron deficiency of compound 2, which also leads to the reversible coordination of THF. Photophysical properties of both compounds in different solvents were investigated. Theoretical studies further support the strong conjugation in the ground state of compound 1 and the electron-deficient property of compound 2.A new coordination polymer [Hg(LI)I]n (1) and a new discrete coordination complex [Hg(HLII)I2] (2) are synthesized and X-ray characterized. The existence of positive π-holes at the spodium atoms in both compounds is evidenced by DFT calculations. In 1, a Hg-S semicoordination bond and a HgI spodium bond are formed at opposite sides of the π-hole. In 2, two different HgI spodium bonds are formed at both sides of the π-hole. This is the first study describing structure-guiding π-hole spodium bonding.The tetradentate N2S2 Schiff base ligands derived from condensing S-methyl or S-benzyl dithiocarbazate with acetylacetone have been found to be versatile chelators for copper and able to stabilise unusually high oxidation states. Herein we report their Ni coordination chemistry and a variety of products ensue depending on the reaction conditions. Unusual examples of linkage isomerism have been observed upon complexation with nickel acetate and these asymmetrically and symmetrically coordinated NiIIN2S2 complexes have been characterised both crystallographically and in solution by NMR. These compounds react rapidly with dioxygen and the ligands are particularly susceptible to oxidation which lead to various products including dinuclear NiII complexes derived from radical homocoupling reactions. These dinuclear NiII complexes are also redox active and spectroelectrochemistry has revealed new electronic transitions from their formally NiIII/NiII mixed valent state.