Ectopic miR-184 overexpression delayed this process in mice. Furthermore, miR-184 transfection into HCECs significantly inhibited cell proliferation, cell cycle progression, and cell migration. MiR-184 directly targeted , , and , and downregulated their expression in HCECs. CARM1 downregulation inhibited both HCEC proliferation and migration, whereas a decrease in LASP1 gene expression only inhibited migration. Our results demonstrate that miR-184 inhibits corneal epithelial cell proliferation and migration via targeting , , and , suggesting it acts as a negative modulator during CEWH. Therefore, identifying strategies to suppress miR-184 expression levels has the potential to promote CEWH. Our results demonstrate that miR-184 inhibits corneal epithelial cell proliferation and migration via targeting CDC25A, CARM1, and LASP1, suggesting it acts as a negative modulator during CEWH. Therefore, identifying strategies to suppress miR-184 expression levels has the potential to promote CEWH. In domestic and per domestic area, insecticides such as DDT, malathion, fenitrothion, propoxur and, more recently, synthetic pyrethroids such as deltamethrin and lambda-cyhalothrin, have been successfully used to control sand flies in many countries. The present study reports the results of time-mortality bioassay to DDT 4%, lambda-cyhalothrin 0.05%, permethrin 0.75%, cyfluthrin 0.15% and deltamethrin 0.05% in recently colonized populations in Iran. The insecticide susceptibility status of laboratory population was assessed during 2016-2017, following the standard WHO technique for mosquito (WHO, 2013) based on diagnostic dose. Sand flies collected from rural area of Badrood (Matin Abad), Natanz County, Esfahan Province, using aspirator. Susceptibility test to DDT and pyrethroids was assessed on 3534 laboratory-reared (1746 females and 1788 males). The LT and LT values were measured using probit analysis and regression lines. The test results against males of revealed that LT values to DDT 4%, Permethrin 0.75%, Deltamethrin 0.05%, Cyfluthrin 0.15% and Lambdacyhalothrin 0.05% were 439.28, 108.90, 97.75, 5.00 and 57.84 seconds. The figures for females were 641.62, 136.15, 146.44, 8.71 and 72.69 seconds, respectively. According to presented results, the reared population of sand flies collected from a hyper-endemic region of Esfahan Province is still susceptible to prethroids and Resistance candidate to DDT 4%. According to presented results, the reared population of sand flies collected from a hyper-endemic region of Esfahan Province is still susceptible to prethroids and Resistance candidate to DDT 4%. Present study was conducted to determine species composition of mosquitoes (larvae, pupae and adults) collected from ten different towns of Lahore from September 2014 to August 2015. Mosquito larvae, pupae and adults (male and female) were collected by using dippers and aspirators from September 2014 to August 2015 in different sites of Lahore comprising of ten towns i.e. Iqbal, Aziz Bhatti, Data Ganj Baksh, Gulberg, Nishtar, Ravi, Samanabad, Shalimar, Wagah, and Lahore Cantonment. Mosquito larvae and adults were identified by standard entomological keys. Diversity, richness and rarity of mosquito fauna were analyzed by the Shannon, Simpson and Margalef indices respectively. In this study, a total of 8656 mosquitoes belonging to four genera namely , , and were identified. Among fifteen species collected, was the most abundant species in the city having 25.8% relative abundance. However ( ) was reported as the least abundant species with 0.22% relative abundance. The highest diversity of mosquitoes was shown in the month of August (H= 2.25) while the lowest diversity was recorded June (H= 1.43). Extensive sewage water supported the maximum abundance of in urban areas of this city. This study has significantly elaborated the monthly varying species composition of mosquito fauna of this city. Hence this research will help us to find out the control strategies of mosquito borne diseases in this region. This study has significantly elaborated the monthly varying species composition of mosquito fauna of this city. Hence this research will help us to find out the control strategies of mosquito borne diseases in this region. Leishmaniasis diseases are known to be one of the most important public health problems in World and Iran. Visceral leishmaniasis is considered to be the most serious form and transmitted by sand flies species. The aim of this study was to investigate the dynamic activities of sandflies in northwestern Iran. This crass-sectional study was conducted from April to December 2018 in Meshkinshahr County, Ardabil Province. Sticky traps have been used to collect sand flies. They are stored in 70% alcohol and finally identified using valid keys. The aspects of the synoptic information were inquired from the Meshkin Shahr weather department and results analyzed for SPSS24. Totally 259 sandflies were collected during study period. From collected samples 78.7% were male and 21.3% female. There were 8 different species. was the most prevalent one (30.8%). The average temperature, relative humidity, and average wind speed was 13.5 °C, 84%, and 2 meters per hour on the onset of sandflies' activity, respectively. These values were 18.3 °C, 85% and 1.5 meters per hour at the peak of their activity and 16 °C, 62% and 5 meters per hour at the final stage of their activity. Sand flies had one peak in July which is strongly influenced by temperature and humidity conditions. Two species of and , had the highest activity in this endemic area. The results of current study will provide a guideline for control of diseases in the country. The results of current study will provide a guideline for control of diseases in the country. The emergence and spread of antibiotic resistant bacteria has become a serious problem worldwide. Houseflies are potential carriers of pathogenic and resistant bacteria and could be contributing to the global spread of these strains in the environments. https://www.selleckchem.com/products/Eloxatin.html We investigated the prevalence and antimicrobial resistant profiles of bacteria isolated from houseflies in Akure. Twenty-five houseflies were captured by a sterile nylon net from the slaughterhouse, garbage dump, human house, hospital, and eatery from 900am to 100pm when the flies were active and transported immediately to the laboratory in sterile containers for processing. Bacterial loads were enumerated by serial dilution and plating on nutrient agar and selective media. Bacteria species were isolated by conventional isolation technique. Antibiotic susceptibility test was determined by the Kirby-Bauer disc diffusion technique. Sixty-seven bacterial species were isolated from 25 samples that were collected. The predominant bacterial species was (n= 31, 45%), followed by (n= 17, 25%), (n= 11, 16%) and (n= 3, 4.