Antiepileptic drug (Preg) and neurotransmitters (Gpn, Gly, Asp, Glu, Ser, GABA and Ade) were used to synthesis a series of ternary Cu2+ complexes. Surface morphology and chemical composition of the complexes were using studied SEM and EDX spectra. Purity, molecular weight and formulae of the complexes were determined from GC-MS spectra and elemental analysis. XRD data and N-Treor implemented in Expo2014 computer program reveal monoclinic crystal system with space group P1 2/c 1 and P 1 21 1 of the complexes. IR spectra exhibited that Preg, Gpn and GABA coordinated to the Cu2+ as monodentate ligand through COOH whereas the amino acids bonded through the -NH2, COO- groups. UV-Vis spectra and magnetic moment values indicated pseudo tetrahedral stereochemistry. ESR spectra showed that the complexes have isotropic and axial structures with dx2-y2 ground state. TGA, DTG and DTA confirm the suggested structure and mechanism for thermal decomposition was suggested. Kinetic and thermodynamic parameters were calculated using Coats-Redfern equation. The complexes [Cu(Preg)(Ser)Cl] and [Cu(Preg)(Ade)Cl2] showed greater anticonvulsant activity compared against PTZ-induced seizures in male Albino mice. Recorded latency time for the complexes [Cu(Preg)(Ser)Cl] and [Cu(Preg)(GABA)(OH)Cl].2H2O was longer than that recorded with Preg indicating higher anticonvulsant effect. Self-assembled peptide gels have generated interest as antibacterial materials to prevent biomaterial-related infections but these peptides are often associated with poor proteolytic stability. Efforts have been made to stabilize peptides by incorporating non-natural amino acids and/or linkages but complexation with polymers have not been explored. Therefore, we developed self-assembled peptide/chitosan gels, Boc-D-Phe-γ4-L-Phe-PEA (NH007)/chitosan and Boc-L-Phe-γ4-L-Phe-PEA (NH009)/chitosan, by complexing dipeptide NH007 or NH009 with chitosan in DMSOacetic acid. The gels were characterized using SEM, FTIR, contact angle, and rheology data and found to exhibit excellent viscoelastic and self-healing characteristics. Complexation with chitosan led to an increase in stability against proteolytic degradation. Peptide/chitosan gels showed broad spectrum antibacterial activities against Gram-negative and Gram-positive bacteria, such as Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, and Bacillus subtilis at a high inoculum of 107-108 cfu/mL. NH007/chitosan gels showed 70-75% inhibition, whereas NH009/chitosan showed 78-81% inhibition and NH009/chitosan gels, in particular, showed strong antibacterial activity against pathogenic strain of P. aeruginosa. A unique feature of these gels is that the antibacterial activities did not decrease gradually but were sustained for up to 48 h. The mechanistic studies using SEM and HR-TEM indicated interaction of gels with bacterial membrane components, leading to cell lysis. The MTT and LDH assays indicated >90% cell viability and only 8-10% toxicity towards NIH 3T3 fibroblast cells. Thus, peptide/chitosan gels developed in the present work showed improved proteolytic stability and sustained antibacterial activities and, therefore, may be used for preventing biomaterial-related infections. Carbon-based nanomaterials have established a prime position as drug delivery carriers. It is very interesting to see that a carbon nanostructure could be used as a drug too, instead of its regular application as a drug delivery carrier. In this aspect, graphene quantum dots (GQDs) are now in the spotlight. GQDs are one of the recent entrants to the list of carbon-based nanomaterials. They are now reported useful in Parkinson's and Alzheimer's diseases. Furthermore, antibacterial and anti-diabetic potentials of GQDs are now known. In addition, they are now widely evaluated for drug delivery application. They have good potential for drug delivery across the blood-brain barrier. Tumor-targeted drug delivery is also possible with GQDs. Their biosensing and bioimaging applications are also under extensive study. In this review, the therapeutic, drug delivery, biosensing and bioimaging applications of GQDs are described. It would be very interesting to speculate the future of GQDs and how this carbon nanomaterial influences the future of nanobiomedicine. It is presumed that drug-GQD duo would be the next generation strategy for many unresolved therapeutic hurdles. Evaluation of the biological properties of silanized graphene oxide is important in the context of biomedical applications of the material. In this study, we have evaluated the toxicity, immunogenicity and other biological properties like osteogenicity of silanized graphene oxide (SiGO). Graphene oxide (GO) was silanized using a common silanizing agent namely (3-aminopropyl) triethoxysilane (APTES). Silanization was confirmed through infrared spectroscopy and elemental mapping. Post-silanization, we did not observe any significant changes in the morphology of GO. Silanization leads to an increase in the interlayer distance and disorder in the lattice. Study of in vitro toxicity of SiGO on three different cell lines namely primary human dermal fibroblast, murine embryonic fibroblast and human osteosarcoma cell lines revealed that toxicity of SiGO was significantly less than GO. We further showed that in vitro immune activation of macrophage was less in the case of SiGO in comparison to GO. Profiling of osteogenic differentiation of human mesenchymal stem cell revealed that SiGO is less osteogenic than GO.  https://www.selleckchem.com/products/valproic-acid.html  Study of acute toxicity in the murine model indicated that GO was hepatotoxic at experimental concentration whereas SiGO did not show any significant toxicity. This study implied that SiGO is a better biocompatible material than GO. BACKGROUND The use of permanent synthetic materials for abdominal wall repair is currently the method of choice. However, they are not ideal as short-term and long-term complications have been reported for these materials including chronic groin pain (pain that lasted longer than 3 months), which occurred in 10-12% of patients, and host immunological responses to foreign body grafts. In the present randomized paired study we compared an electrospun composite scaffold composed of poly (l-lactide-co-caprolactone) [PLCL] blended with porcine fibrinogen (F-Fg) (PLCL/F-Fg), with a polypropylene mesh (PPM) as the control in a canine abdominal wall defect model (in 36 Beagle dogs). RESULTS A blend ratio of 41 PLCL F-Fg1 scaffold possessed optimal physical characteristics including shrinkage rate, mechanical strength, porosity and super-hydrophilic properties. Macroscopic, histological and biomechanical evaluations were performed over a period of 36 weeks and the results indicated that the resorbable PLCL/F-Fg1 electrospinning scaffold could effectively induce and augment abdominal skeletal muscle regeneration.