Our results provide a reference towards designing NSSI prevention programs geared toward the high school population during the COVID-19 pandemic.The present research aims to analyse the psychometric properties of the AF5 questionnaire for its adaptation for use with young people during a lockdown period. Research was conducted with a sample of 534 students aged between 13 and 17 years (M = 14.49; SD = 1.805). Exploratory factor analysis was conducted using the FACTOR program and confirmatory factor analysis was conducted using the M-PLUS 7 program. Results indicate that a four-dimensional model is most appropriate for bringing together the emotional and physical dimensions. Further, 11 items were removed due to poor factor loadings. The majority of factors were directly and positively correlated (99%; p  less then  .01). The data obtained supports conclusions that the AF-5 meets validity and reliability requirements for it to be considered a useful instrument for use with young people during the COVID-19 lockdown period.With the COVID-19 outbreak, the population was suddenly forced to "stay at home". Although research suggests that social isolation affects health and wellbeing, reactions may vary depending on individuals. The current study assessed the relationships between personality variables (preference for solitude and Big Five personality), mental health (anxiety, stress, loneliness), and creativity, and tried to determine whether the identified personality profiles affect individuals' mental health and creativity. French respondents (N = 430) filled in an online questionnaire during the first lockdown in Spring 2020. The results showed that the preference for solitude and personality variables of the Big Five predicted individuals' mental health and creativity. Moreover, a cluster analysis revealed three profiles of individuals "Affiliation", "Emotionally Stable Lonely" and "Emotionally Unstable Lonely". Results showed that individuals with "Affiliation" and "Emotionally Unstable Lonely" profiles expressed higher stress and anxiety, and the latter performed better on a divergent creative thinking task. By contrast, those with an "Emotionally Stable Lonely" profile expressed a lower level of loneliness, and performed better on a creative insight task. These findings reveal the importance of personality profiles in psychological reactions during lockdowns. With this knowledge, health professionals could develop appropriate interventions to accompany high-risk individuals in situations of social isolation.
  The online version contains supplementary material available at 10.1007/s12144-021-01885-3.
 The online version contains supplementary material available at 10.1007/s12144-021-01885-3.Researchers tout digital learning as a tool that can increase the authenticity of student learning and assessment tasks but lack a psychometrically valid instrument to test this hypothesis. Further, there are several complementary definitions of authentic work, versus a single agreed upon definition, presented in academic literature. I synthesized this literature to develop the Authentic Online Work Rubric that measures two primary components of authentic online work - opportunities for higher-order thinking and real-world relevance. Data were collected from online courses developed by one of the largest online course providers in the United States. I validated the scale using principal component analysis before generating a lesson-level standardized coefficient using item response theory for both the higher-order thinking and real-world relevance subscales. The use of this rubric facilitates the measurement of authentic work and is targeted for use in the evaluation of learning tasks and assessments in online instructional settings to support researcher, developer, and school-based continuous improvement processes.Lesbian, gay, bisexual, transgender, and queer (LGBTQ) individuals disproportionately experience intimate partner violence (IPV) and resulting negative health consequences compared to cisgender heterosexual individuals. This study builds on prior recent work by examining specific trauma-informed care (TIC) components most associated with a comprehensive set of health and psychosocial risks among 298 LGBTQ IPV survivors who sought and accessed trauma-related services (e.g., mental health counseling). Results indicated that TIC components are differentially associated with LGBTQ clients' health and well-being. Specifically, greater perceptions of providers who fostered agency and mutual respect were associated with better outcomes, whereas greater perceptions of providers who focused on culture and increasing opportunities to connect with other survivors were related to negative outcomes.  https://www.selleckchem.com/products/cb-839.html  These findings underscore the need for providers to prioritize LGBTQ clients' sense of agency and mutual respect and identify for whom focusing on culture and connecting with other LGBTQ survivors might be beneficial.
  Although cyclophosphamide (CPA) is the key drug for the treatment of autoimmune diseases including vasculitides, it has some well-known adverse effects, such as myelosuppression, hemorrhagic cystitis, infertility, and infection. However, CPA-associated severe enteritis is a rare adverse effect, and only one case with a lethal clinical course has been reported. Therefore, the appropriate management of patients with CPA-associated severe enteritis is unclear.
 
  We present the case of a 61-year-old woman diagnosed with granulomatosis with polyangiitis based on the presence of symptoms in ear, lung, and, kidney with positive myeloperoxidase-antineutrophil cytoplasmic antibody. She received pulsed methylprednisolone followed by prednisolone 55 mg/d and intravenous CPA at a dose of 500 mg/mo. Ten days after the second course of intravenous CPA, she developed nausea, vomiting, and diarrhea, and was admitted to the hospital. Laboratory testing revealed hypoalbuminemia, suggesting protein-losing enteropathy. Computed tomography revealed wall thickening of the stomach, small intestine, and colon with contrast enhancement on the lumen side. Antibiotics and immunosuppressive therapy were not effective, and the patient's enteritis did not improve for > 4 mo. Because her condition became seriously exhausted, corticosteroids were tapered and supportive therapies including intravenous hyperalimentation, replenishment of albumin and gamma globulin, plasma exchange, and infection control were continued. These supportive therapies improved her condition, and her enteritis gradually regressed. She was finally discharged 7 mo later.
 
  Immediate discontinuation of CPA and intensive supportive therapy are crucial for the survival of patients with CPA-associated severe enteritis.
 Immediate discontinuation of CPA and intensive supportive therapy are crucial for the survival of patients with CPA-associated severe enteritis.