https://www.selleckchem.com/products/rin1.html The methodological qualities, including the risk of bias, will be evaluated using the Cochrane risk of bias assessment tool. After screening the studies, a meta-analysis of the RCTs will be performed, if possible. This study is expected to generate high-quality evidence of the efficacy and safety of herbal medicines to treat post-stroke constipation. Our systematic review will provide evidence to determine whether herbal medicines can be effective interventions for patients with post-stroke constipation. Ethical approval is not required, as this study was based on a review of published research. This review will be published in a peer-reviewed journal and disseminated electronically and in print. Research registry reviewregistry1117. Research registry reviewregistry1117. Shoulder pain is a common musculoskeletal disorder prompting many patients to seek treatment. Acupotomy is a common treatment for shoulder which has been widely used in hospitals. But its efficiency has not been scientifically and methodically evaluated. This protocol aims to evaluate the efficacy and safety of acupotomy for treating shoulder pain. Relevant studies will be searched from the databases of PubMed, EMBASE, Cochrane Library, China Knowledge Resource Integrated Database, Weipu Database for Chinese Technical Periodicals, SinoMed, and Wanfang Database. Two researchers will independently select studies, collect data, and assess the methodology quality by the Cochrane risk of bias tool. The systematic review will provide high-quality evidence to assess the efficacy and safety of acupotomy for shoulder pain as well as adverse events. The systematic review will provide evidence to assess the effectiveness and safety of acupotomy therapy for shoulder pain patients. INPLASY 202130002. INPLASY 202130002. Percutaneous coronary intervention (PCI) is an effective revascularization strategy in patients with coronary heart disease (CHD). However, recent st