https://www.selleckchem.com/products/cpi-444.html RESULTS Pooling five clinical trials (five treatment arms) together did not show any significant effect on body weight (WMD -0.74 kg, 95% CI -3.17 to 1.69) and body mass index (BMI) (WMD -1.47, 95% CI -4.07 to 1.12). Our results illustrated that a significant decrease of fasting blood sugar (WMD -5.32, mg/dL95% CI -10.46 to -0.17), fasting insulin (WMD -4.10, μIU/dL95% CI -6.76 to -0.144) and HOMA-IR (WMD -0.69 95% CI -1.37 to -0.004) were observed after cinnamon treatment. Moreover, our findings demonstrated that oral cinnamon supplementation in PCOS patients led to significant reduction of serum level of LDL-C, total cholesterol, and triacylglycerol. Besides, an improvement of serum concentration of HDL-C was shown by cinnamon supplementation. CONCLUSION Generally, present study indicated that cinnamon supplementation may help PCOS patients to manage their metabolic parameters. Future prospective randomized clinical trials with longer intervention duration are warranted to obtain a precise conclusion. V.ETHNOPHARMACOLOGICAL RELEVANCE The dicotyledonous plant Piptadeniastrum africanum (hook.f.) Brennan (Fabaceae) is used in traditional medicine to treat various human complaints including bronchitis, cough, various urino-genital, meningitis, abdominal pain, wound treatment malaria and gastrointestinal ailments and as a purgative and worm expeller. AIM OF THE STUDY The present study describes the phytochemical investigation and the determination of the antimicrobial, antiplasmodial and antitrypanosomal activities of fractions and compounds extracted from Piptadeniastrum africanum roots. MATERIALS AND METHODS Isolated compounds were obtained after several chromatographic techniques. The structures of all compounds were determined by comprehensive spectroscopic analyses (1D and 2D NMR) and by comparing their NMR data with those found in literature. In vitro antimicrobial activity of samples was evaluated using the micro