Farfugium japonicum (L.) Kitam. var. giganteum (Siebold et Zucc.) Kitam. is mainly distributed in the Kyushu and Shikoku Islands of Japan. The main aim of this study was to isolate and identify the chemical constituents of the 70% EtOH extract of the flowers of F. japonicum var. giganteum and to evaluate their tyrosinase inhibitory and free radical scavenging activities.  https://www.selleckchem.com/products/iberdomide.html  Five phenolic compounds, namely petasiphenol (1), rosmarinic acid (2), 4,5-di-O-caffeoylquinic acid (3), 5-O-caffeoylquinic acid (4) and quercetin (5) were isolated and their structures were elucidated on the basis of NMR spectroscopic data. All these compounds were isolated for the first time from title plant. Among them, petasiphenol (1) showed potent tyrosinase inhibitory activity followed by quercetin (5) and 4,5-di-O-caffeoylquinic acid (3). All of these compounds showed potent free radical scavenging activity.Splenic artery (SA) originating from the superior mesenteric artery is a rare condition, and aneurysms in relation to this aberrant SA are even rarer. We reported the case of a 67-year-old female who presented with painless progressive jaundice for 2 months accompanied by thrombocytopenia and liver dysfunction. The computed tomographic angiography (CTA) showed an aberrant SAA located behind the pancreatic head along with the dilation of common bile duct. Stent-graft deployment in SMA and coil embolization of the aneurysm were performed. Her liver dysfunction and thrombocytopenia improved postoperatively. CTA at 2-year follow-up showed patency of stent-graft and SMA and the shrinkage of the excluded aneurysm sac. Considering the particular location of the aneurysm, painless progressive jaundice can be the initial symptom for the aberrant SAAs. This combined endovascular technique completely excluded the aneurysm and was beneficial for treating secondary liver dysfunction and thrombocytopenia.A coronary stent is a conventional medical device used in percutaneous coronary intervention (PCI), and its mechanical properties have become one of the critical factors to determine the effect of surgical treatment. Based on the existing cobalt-chromium (CO-Cr) alloy L605 coronary stent, this paper established an integrated finite element model of the stent-balloon-compression shell to simulate the stent bundle expansion test and crush resistance test with parallel plates. We verified the accuracy of the analytical model by comparing the simulation results with experimental results. The effects of different parameters on the axial retraction performance, the expansion uniformity, and the flexibility of the stent are analyzed by using the support body dimension and connector form as parameters. The results demonstrate that increasing the number and length of the circumferential support can improve the axial retraction performance, expansion uniformity, and the form of the connector has a significant influence on the flexibility of the stent. Finally, the optimized CO-Cr alloy stent with improved comprehensive indicators is described.
  The efficacy and safety of non-vitamin K antagonist oral anticoagulants (NOACs) combined with antiplatelet drugs in patients with peripheral artery disease remain largely unknown.
 
  The aim of this meta-analysis was to explore the effects of NOACs combined with antiplatelet drugs versus antiplatelet drugs alone in this population.
 
  A comprehensive search of randomized controlled trials published in PubMed, EMBASE, Web of Science, and the Cochrane Library in 30 September 2020 and before. According to the I
  statistic, a random or fixed-effect model was used to analyze the safety and effectiveness of NOACs combined with antiplatelet drugs in peripheral artery disease patients.
 
  Three RCTs met the inclusion criteria, with a total sample size of 11,761 participants. Compared with antiplatelet drugs alone, NOACs combined with antiplatelet drugs resulted in lower risk of ischemic stroke events (OR = 0.75, 95%CI 0.57-0.98, 
  =
  0.03), while other treatment effects were not worse than those of single antiplatelet drugs (
  ≥
  0.05). In addition, although compared with single antiplatelet drugs alone, NOACs combined with antiplatelet drugs had a higher risk of major bleeding and clinically related nonmajor bleeding, their risk was not higher for intracranial hemorrhage, which may endanger the life of patients, or for fatal bleeding.
 
  In summary, for peripheral artery disease patients, a combination of NOACs plus antiplatelet drugs may offer additional benefit in reducing ischemic stroke outcome, yet it may increase the risk of bleeding.
 In summary, for peripheral artery disease patients, a combination of NOACs plus antiplatelet drugs may offer additional benefit in reducing ischemic stroke outcome, yet it may increase the risk of bleeding.Slope failure in municipal solid waste (MSW) landfills is a common environmental disaster that poses serious ecological and health risks. Landfill slope stability (SS) is sensitive to leachate levels and gas pressure (GP) caused by the degradation of organic material, but the extent of these combined effects remains poorly understood. In this study, a simplified landfill GP calculation method is presented and a circular slide method that considers the combined effects of leachate and GP is established. The results show that the landfill GP is mainly affected by the gas production rate, gas conductivity of the solid waste (SW), and landfill depth. The safety factor of landfill SS is also significantly lower when GP is considered. The distribution of GP is affected by the depth of the failure circle and SW. Landfill slope instability can be explained by localized damage caused by GP breakthrough of the filled SW. This study probably provides important guidance for the design, operation, and management of MSW landfills.We report a case of a 50-year-old man with a 10-year history of pedicle screw internal fixation in the thoracic spine and heroin abuse, who presented with sudden-onset massive hemoptysis with hemorrhagic shock and asphyxia. Urgent contrast-enhanced chest computed tomography (CT) characteristically showed thoracic aortic perforation, a paravertebral pseudoaneurysm, and an intrapulmonary hematoma. Emergency percutaneous thoracic endovascular aortic repair (pTEVAR) with the preclose technique using a vascular closure device under local anesthesia achieved success without any complications. The current case highlights the importance of understanding massive hemoptysis caused by an aortobronchial fistula related to pedicle screw impingement in clinical practice and the value of pTEVAR with the preclose technique under local anesthesia in the emergency setting.