Vouchers distributed to patients ≤18 years (49/163; 30%) were less likely to be redeemed compared to those distributed to patients >18 years (322/736; 44%; p=0.001).  https://www.selleckchem.com/products/pargyline-hydrochloride.html  Just over half of vouchers were redeemed the same day (195/351; 56%) and ≤1 mile from the clinical site (188/349; 54%). After excluding an outlier site, vouchers accompanied by EPT prescriptions including a partner name (15/27; 56%) were more likely to be redeemed than those lacking a name (83/244; 34%; p=0.03). CONCLUSIONS Less than half of EPT prescriptions were filled, even when medication was free. Whenever possible, EPT should be provided as drug-in-hand.BACKGROUND HIV self-tests increase HIV status awareness by providing convenience and privacy, although cost and access may limit use. Since 2015, the New York City (NYC) Health Department has conducted five waves of an online Home Test Giveaway. METHODS We recruited adult cisgender men who had sex with men (MSM) and transgender and gender non-conforming (TGNC) individuals who had sex with men, living in NYC, who were not previously HIV-diagnosed, using paid digital advertisements (4-8 weeks per wave). Eligible respondents were emailed a code to redeem on the manufacturer's website for a free HIV self-test and an online follow-up survey ~2 months later. For key process and outcome measures, we present means across five waves. RESULTS Over five waves of Home Test Giveaway, there were 28,921 responses to the eligibility questionnaire; 17,383 were eligible; 12,182 redeemed a code for a free HIV self-test; and 7,935 responded to the follow-up survey (46% of eligible responses). Among eligible responses, approximately half were Latino/a (mean 32%) or non-Latino/a Black (mean 17%). Mean report of never-testing before was 16%. Among 5,903 follow-up survey responses that reported test use, 32 reported reactive results with no known previous diagnosis (0.54%), of whom, 78% reported receiving confirmatory testing. Report of likelihood of recommending the Home Test Giveaway to friends was high (mean 96%). CONCLUSIONS We recruited diverse NYC MSM and TGNC and distributed a large number of HIV self-tests to them. Among respondents who reported newly reactive tests, the majority reported confirmatory testing. This appears to be one acceptable way to reach MSM and TGNC for HIV testing, including those who have never tested before.BACKGROUND Anogenital warts (AGW) are a common therapeutic challenge. All therapies are associated with burning, pain and frustrating high rate of recurrence. The search for a new alternative continues. Recently a diterpene ester extracted from the Euphorbia Peplus plant (Ingenol mebutate (IM)) has been shown to possess activity against anogenital warts. OBJECTIVE To compare and evaluate the therapeutic efficacy and safety of topical .05% ingenol gel with another herbal extract medication ( topical 25% podophyllin solution) in treatment of AGWs. METHODS This was a comparative single blinded non-randomized, 2-arm trial of Ingenol .05% gel versus podophyllin solution 25% administered up to 6 times to patients with AGWs. To evaluate the therapeutic efficacy, the complete clearance rate and recurrence rate were assessed one week and 12 weeks after last treatment respectively. Safety was assessed by occurrence and severity of pain and local skin reaction (LSR). RESULTS Out of 31 and 36 patients in IM group and podophyllin group who completed the study, initial complete resolution was observed in 20 (64.5%) and 14(38.9%) patients respectively P=0.03. The initial clearance was faster in the IM group (2.00±0.91 weeks) compared with podophyllin group (4.21±1.05 weeks), P= 0.00. After 3 months, recurrence was seen in 13/20 (65.0%) patients in IM group and 6/14 (42.8%) in podophyllin group, P=0.20.The number of patients with complete resolution after 3 months was not different between two groups ( 7/31 in IM group and 8/36 in podophyllin group, P=0.9). The mean±SD severity score for LSR and pain in IM group was 6.65±1.76 and 6.13±2.57 respectively, which was significantly higher than their scores (3.39±1.57 and 2.58±1.38) in podophyllin group P=0.00. CONCLUSION IM .05% gel is effective as podophyllin 25% solution in treating AGWs with further benefit of being much more rapid. However, high recurrence rate, sever pain and local skin reaction limit its use.In a vaginal 16S ribosomal RNA gene quantitative PCR study of 17 pelvic inflammatory disease (PID) cases and 17 controls who tested positive for Chlamydia trachomatis, women who additionally tested positive for Atopobium vaginae, Sneathia spp., BVAB-TM7, Megasphaera spp., Eggerthella-like bacterium or Mobiluncus spp. were more likely to develop PID.BACKGROUND Gonorrhea and chlamydia are common among Chinese men who have sex with men (MSM), but testing rates are low. We developed a pay-it-forward program where men receive a free gonorrhea/chlamydia test and can then donate toward future participants' tests. This study aims to investigate drivers of testing uptake and donation using a mixed methods approach. METHODS We used a sequential explanatory design to explore drivers of testing uptake and donation unique to pay-it-forward through a quantitative cross-sectional survey and a qualitative thematic analysis of semi-structured interviews.We collected data on socio-demographics and perceived benefits of pay-it-forward among men offered the pay-it-forward interventionand analyzed testing uptake and donations using descriptive statistics and logistic regression. We then conducted thirty semi-structured interviews with men and codedinterview data to identify themes. RESULTS 301 MSM were offered pay-it-forward and 55% (165/301) received gonorrhea/chlamydia testing. 91% (150/165) donated any amount with a mean of 58.31±53.39 RMB ($8.61±7.88 USD), or 39% of the standard price of gonorrhea/chlamydia testing. Getting tested was not associated with income, but donations were higher in the highest income bracket (aOR = 7.12, 95% CI = 1.61-31.52). 58% (94/162) selected "more MSM can get tested" and 54% (88/162) selected "I can help someone else" as benefits of pay-it-forward. Qualitative themes for drivers of testing and donation included flexible pricing, generosity and reciprocity, and MSM community identity. CONCLUSIONS Quantitative and qualitative results suggest that this pay-it-forward program may increase gonorrhea/chlamydia testing by reducing cost barriers, leveraging generosity and reciprocity, and mobilizing community altruism.