Medical Panels undertake assessments of injured workers under compensation legislation in both Victoria, Australia, and Alberta, Canada. However, the status afforded the medical answers provided differs markedly between the two jurisdictions. This column considers the nature and implications of these differences.Tourette's disorder is a stigmatising developmental neuropsychiatric disorder usually commencing in early childhood and lasting for varying periods and intensities, with persistence into adulthood for about one-third of those affected as children. The potential forensic relevance of the disorder, in the context of its common comorbidities, is relatively little appreciated among forensic psychiatrists and psychologists, legal practitioners and judicial officers in spite of the fact that a significant number of young persons and adults with Tourette's disorder are charged with criminal offences. This editorial reviews the clinical and forensic literature, about the disorder, as well as significant superior court and appellate judgments and argues for better education about the relevance of the disorder for assessments of criminal culpability, likelihood of recidivism and the consequences of custodial confinement for offenders with Tourette's disorder. It identifies areas for constructive further research.Sexual health in later life is becoming increasingly important as more people are reaching older age and are remaining sexually active well into their seventies and beyond. Alongside this, as more older people seek new relationships following partner death or divorce, the rates of newly diagnosed sexually transmitted infections are increasing markedly. This article focuses on sexual health and well-being. It offers a definition of sexual health and explores the changes that people experience in sexual health, well-being and functioning in later life. It discusses common physical, psychosocial and sexual relationship issues, and identifies advice that nurses can offer to older people. Using the PLISSIT model, it then focuses on the role of nurses in promoting sexual health for people in later life. © 2020 RCN Publishing Company Ltd. All rights reserved. Not to be copied, transmitted or recorded in any way, in whole or part, without prior permission of the publishers.SIGNIFICANCE The diagnostic depth of photodynamic diagnosis (PDD) for gastric cancer with protoporphyrin IX (PpIX) is limited, which leads to missing intramucosal cancers in screening and surgery. AIM The reason is that the excitation light, whose wavelength is determined by the highest absorption peak of PpIX (∼405  nm), is strongly attenuated by mucosal tissues. We investigated an excitation wavelength that can extend the diagnostic depth of PpIX fluorescence at the mucosal subsurface. APPROACH By calculating the depth-dependent intensity of the excitation light in porcine gastric mucosa for each wavelength, relationships among the wavelength, fluorophore depth, and fluorescence intensity were assessed and fluorescence images of PpIX pellets located at different fluorophore depths were compared experimentally by changing the excitation wavelength. RESULTS The numerical calculation showed that a 505-nm excitation light provided the highest fluorescence intensities at a fluorophore depth deeper than 1.1 mm. In the fluorescence observation, the fluorescence intensities at fluorophore depths of 0 and 1.0 mm at 405 nm were 5.4  ×  103 and 1.0  ×  103  arb. units, whereas those at 505 nm were 5.3  ×  101 and 1.9  ×  102  arb. units, respectively. CONCLUSION The experimental results suggest that the diagnosis depth of PDD with PpIX for intramucosal cancer can be extended by 505-nm excitation light.We demonstrate dual modality of free-space fluorescence diffuse optical tomography (FDOT) and handheld ultrasound (US) imaging to reveal both functional and structural information in small animals. FDOT is a noninvasive method for examining the fluorophore inside an object from the light distribution of the surface. In FDOT, a 660-nm continuous wave diode laser was used as an excitation source and an electron-multiplying charge-coupled device (EMCCD) was used for fluorescence data acquisition. Both the laser and EMCCD were mounted on a 360-deg rotation gantry for the transmission optical data collection. The structural information is obtained from a 6- to 17-MHz handheld US linear transducer by single-side access and conducts in the reconstruction as soft priors. The rotation ranges from 0 deg to 360 deg; different rotation degrees, object positions, and parameters were determined for comparison.  https://www.selleckchem.com/products/Sodium-butyrate.html  Both phantom and tissue phantom results demonstrate that fluorophore distribution can be recovered accurately and quantitatively using this imaging system. Finally, an animal study confirms that the system can extract a dual-modality image, validating its feasibility for further in vivo experiments. In all experiments, the error and standard deviation decrease as the rotation degree is increased and the error was reduced to 10% when the rotation degree was increased over 135 deg.in English, French Au cours des dernières décennies, on observe un nombre croissant de cas d’insuffisance rénale chronique et terminale en Amérique centrale et en Asie. Celle-ci touche surtout des jeunes agriculteurs sans autre facteur de risque rénal. La symptomatologie inclut une baisse progressive de la filtration glomérulaire, et une protéinurie minime, avec à la biopsie une néphrite tubulo-interstitielle. Un lien étroit avec le réchauffement climatique a été évoqué pour cette maladie nommée selon la région néphropathie mésoaméricaine, sri lankaise ou néphropathie d’étiologie inconnue. Une autre hypothèse est la consommation d’eau contaminée par des pesticides. Dans cet article, nous ferons le point sur cette nouvelle maladie rénale. La prévention de l’insuffisance rénale aiguë pendant les périodes de forte chaleur en Suisse est également discutée.in English, French La survenue d’un diabète après transplantation rénale est une entité fréquemment rencontrée tant par le néphrologue, le diabétologue que par le médecin de premier recours. Cet article fait le point sur différents aspects liés au diabète après transplantation rénale tels que l’épidémiologie, les facteurs de risque, la pathogenèse, le diagnostic, les complications associées et la prise en charge thérapeutique.