https://www.selleckchem.com/products/AM-1241.html To assess the direct costs of distal radius fracture volar plate (VP) fixation and to create a model to examine the effect of these cost-drivers. Retrospectively, 744 distal radius fractures treated with open reduction and internal fixation (ORIF) were identified. The outcomes assessed included (1) the direct costs related to distal radius ORIF and (2) if a VP alone was amenable. Costs were represented as a cost-ratio relative to the average cost of distal radius ORIF, where the average value is set as 1.0. Simulation models were run with all cost-drivers (sex, age, open fracture, intra-articular fracture, ancillary fixation) and with only ancillary fixation as a cost-driver. The cost-ratio ranged from 0.61-1.81 and ancillary fixation was associated with increased implant costs in multivariable analysis. In the simulations, the cost-ratio ranged from 0.96-1.23 when all cost-drivers were included and 0.99-1.20 if only ancillary fixation was included as a cost-driver, a reduction of the range by 22.2%. Older patients, females, closed fractures and extra-articular fractures were more amenable to VP fixation alone. Eighty-three percent of the surgically treated distal radius fractures were treated with volar plate fixation alone. A disposable kit could help limit cost variance per case by roughly 22%, as only ancillary fixation varies these costs. Closed fractures and extra-articular fractures in older patients or female patients are more amenable to volar plate fixation alone. Eighty-three percent of the surgically treated distal radius fractures were treated with volar plate fixation alone. A disposable kit could help limit cost variance per case by roughly 22%, as only ancillary fixation varies these costs. Closed fractures and extra-articular fractures in older patients or female patients are more amenable to volar plate fixation alone. The purpose of this study was to determine if the thickness of splint padding cou