It is good for the nuclear medicine technologist to be aware of the normal variants and the appearance of a good-quality scan. The primary responsibility as a nuclear medicine technologist is to provide an optimal quality scan that maximizes the reading physician's ability to correctly interpret while using current radiation safety practices as the best possible experience is created for patients and families. Combining the radiation safety aspects (nuclear) with how care is provided (medicine) and the use of the most recent equipment (technology) is what defines a nuclear medicine technologist.The progress made in hybrid PET imaging during the past decades has significantly expanded the role of this modality in both clinical and research applications. Semi-quantitative PET/CT has been the workhorse of clinical PET/CT due to its simplicity and availability. In addition to semi-quantitative PET/CT, volumetric PET and global metabolic activity have recently shown promise in a more accurate assessment of various diseases. PET/CT has been widely used in pediatric oncologic and non-oncologic diseases. Here we have highlighted few of the pitfalls in the quantitative PET/CT and their potential remedies which have potential in PET/CT evaluation of pediatric diseases.In the current diagnostic paradigm, the substantial physical sensitivity gain is the main advantage of total-body (TB) PET/computed tomography (CT). Therefore, it is up to the imaging community to tailor protocols that take advantage of this unique innovation as it relates to the needs of the pediatric population. However, the paradigm-shifting promise of TB-PET/CT lies in its capability to perform dynamic, delayed, and low-dose imaging, which have the potential to vastly increase the range of diseases and disorders that can be investigated or managed using molecular imaging.Add "improving" before "detection"? PET/MR is beneficial particularly in pediatric patients who undergo recurrent imaging, such as those with cancer or chronic inflammatory disease. PET/MR has advantages compared with PET/computed tomography, including decreased radiation exposure and superior characterization of soft tissue. Ongoing challenges include reducing examination duration and costs and detection of pulmonary lesions. Accepted clinical applications of PET/MR in pediatric patients are evaluation of epileptic foci and diagnosis, staging, and follow-up of solid tumors. PET/MR also may have a role in diagnosis and management of infectious and inflammatory conditions relevant to the pediatric population, including osteomyelitis and Crohn disease.18F-fluorodeoxyglucose (FDG) PET/computed tomography (CT) is an efficient method of diagnosing, staging, treatment evaluation, and recurrence monitoring of pediatric diseases. FDG has some limitations, but other PET/CT tracers have shown promising roles in evaluation of pathologies in pediatric patients. FDG is the most commonly used PET tracer but can accumulate in different types of infection and inflammation. In recent years, more non-FDG tracers have shown utility in evaluating pediatric disease. This article reviews currently available literature on the clinical application of non-FDG PET tracers in the application in the pediatric population.Uterus transplantation (UTx) is the only available treatment for human beings who cannot carry children out to term. However, despite several clinical studies with a very limited number of UTx many issues have to be addressed. Up to date, there is a limited number of successful UTx with livebirth and the majority was achieved with live donors. Wide clinical application is inherently limited by the lack of organs, ischemia/reperfusion injury (IRI) as well as immunosuppression after UTx. The objective of this comprehensive literature review is to discuss these arising limitations of UTx with main focus on strategies to reduce IRI. This review showed, that usage of immunosuppressants, opioids or supplements, like amino acids, protects uterus from IRI, improving rising level of antioxidants and decreasing level of oxidative stress markers.  https://www.selleckchem.com/Caspase.html  The available data of experimental and clinical studies was compiled and will be discussed.The aging process causes detrimental changes in a variety of organ systems. These changes include lesser ability to cope with stress, impaired repair mechanisms and decreased cellular functional reserve capacity. Not surprisingly, aging has been associated with increased susceptibility of donor heart and kidneys grafts to ischemia reperfusion injury (IRI). In the context of liver transplantation, however, the effect of donor age seems to be less influential in predisposing the graft to IRI. In fact, a widely comprehensive understanding of IRI in the aged liver has yet to be agreed upon in the literature. Nevertheless, there have been many reported implications of increased liver donor age with poor clinical outcomes besides IRI. These other poor outcomes include earlier HCV recurrence, increased rates of acute rejection and greater resistance to tolerance induction. While these other correlations have been identified, it is important to re-emphasize the fact that a unified consensus in regard to liver donor age and IRI has not yet been reached among researchers in this field. Many researchers have even demonstrated that the extent of IRI in aged livers can be ameliorated by careful donor selection, strict allocation or novel therapeutic modalities to decrease IRI. Thus, the goals of this review paper are twofold 1) To delineate and summarize the conflicting data in regard to liver donor age and IRI. 2) Suggest that careful donor selection, appropriate allocation and strategic effort to minimize IRI can reduce the frequency of a variety of poor outcomes with aged liver donations.In the present study we systematically re-analyzed results from meta-analyses and genome-wide association studies (GWASs) to assess the credibility of genetic associations with acute rejection risk in renal transplantation. A comprehensive literature search was performed on PubMed, Web of Knowledge, Cochrane library, and Open Grey up to July 2019. Methodological quality of systematic meta-analyses was assessed by the AMSTAR tool. Credibility of genetic associations was assessed by employing the Venice criteria and two Bayesian statistical approaches, the false positive report probability (FPRP) and the Bayesian false discovery probability (BFDP). Sixteen systematic meta-analyses, with a moderate-high quality score (median AMSTAR score 9, range 6-11) and 1 GWAS fulfilled the inclusion criteria. Overall, our systematic re-analysis has identified 9 polymorphic variants in 8 genes (ACE, CD28, CTLA-4, CYP3A5, IFNG, TNF-α, PTPRO and CCDC67) as potential risk factors for acute renal graft rejection. At the pre-specified prior probability of 0.