https://www.selleckchem.com/products/pf-06650833.html The pks + E. coli metabolite colibactin caused a unique mutational signature in intestinal organoids. ©2020 American Association for Cancer Research.A new method called MicroMapping can identify nanoscale protein-protein interactions on live cells. ©2020 American Association for Cancer Research.A chemotherapy-induced shift to ICOSL+ B cells in breast tumors correlated with better survival. ©2020 American Association for Cancer Research.A large international study found that the composition of the intestinal microbiome can predict clinical outcomes in patients undergoing allogenic hematopoietic-cell transplant (HCT) for blood cancers. The findings may help assess patients' transplantation-related mortality risk and aid in developing interventions to prevent or mitigate microbiome changes that affect HCT outcomes. ©2020 American Association for Cancer Research.Symmetric division of stem cells positive for gastrin receptor CCK2R is linked to gastric cancer. ©2020 American Association for Cancer Research.INTRODUCTION Pre-malignant cervical disease and invasive cervical cancer present a significant global health burden with respect to morbidity and mortality, mostly in low- and middle-income countries. Human papillomavirus (HPV) infection typically manifests for the first time in adolescence. We aimed to identify adolescent sociodemographic and anthropometric characteristics associated with subsequent risk for pre-malignant cervical disease and cervical cancer, in a country that offers free screening and HPV vaccines. METHODS This historical cohort study included 969 123 Israeli women examined and anthropometrically measured at age 17 years between January 1967 and December 2011. Data on pre-malignant disease and invasive cervical tumors were obtained from the national cancer registry by linkage. We excluded non-Jewish minorities (a total of 25 472 women) and orthodox/ultraorthodox Jewish women since these populations