INTRODUCTION In-hospital mortality is an important outcome of hospital admission. OBJECTIVES To identify predictors that are independently associated with non-surgical units' in-hospital mortality. PATIENTS AND METHODS The National Health Fund database provided data from 2014 on 2,855,029 hospitalizations of adults, unrelated to surgical procedures.  https://www.selleckchem.com/products/ly333531.html  Analyzed mortality predictors were the patients' age and gender, diagnosis-related group category assigned to the hospitalization, length of the hospitalization, type of hospital and admission, day of week and month of admission. RESULTS The mean in-hospital mortality rate was 4.1%. Odds for in-hospital death increased with patients' age. The female gender was associated with a lower odds of death than the male gender. Among the diagnosis-related groups assigned to the hospitalizations, the highest mortality was found for vascular diseases (11.95%). Considering the length of hospitalization, it was found that the lowest mortality occurred during 5-7-day hospitalizations (2.63%). Compared with clinical hospital, the odds of death was 1.31-fold higher for regional hospitals, 1.35-fold higher for private hospitals and 1.48-fold higher for county/town hospitals; 92% of all in-hospital deaths occurred after urgent and emergency admissions. Hospital admissions at weekends or other non-working days (bank holidays) were statistically significant predictors of in-hospital death. There were differences in mortality between particular months, but there was no seasonal relationship. CONCLUSIONS Age, male gender, emergency admission, admission during the weekend or on another non- working day (bank holiday) and hospitalization in a county/town, private or regional hospital (vs teaching hospital) are factors associated with higher mortality in non-surgical units.INTRODUCTION A new direction in the study of obesity-related problems resulted from the discovery of adipose tissue secretory function. Adipokines are present not only in the blood but also in the saliva. Many scientific reports indicate that obesity affects their salivary concentration. OBJECTIVES To evaluate selected inflammatory markers in the saliva of people with obesity and determine their discriminatory values. PATIENTS AND METHODS The study included 125 patients (82 female and 43 male), between 20 to 65 years of age. The study group consisted of 59 patients with obesity (BMI [body mass index] >30 kg/m2), and the control group 66 patients with normal body weight (BMI less then 25 kg/m2). From all subjects mixed saliva samples were collected to determine the concentration of the following selected markers of inflammation receptor 1 and receptor 2 for tumor necrosis factor-alpha (TNFα-R1 and TNFα-R2), pentraxin 3 (PTX-3), interleukin 15 (IL-15), monocyte chemoattractant protein-1 (MCP-1), soluble intercellular adhesion molecule-1 (sICAM-1) and soluble CD40 Ligand (sCD40L). RESULTS Significantly higher levels of selected salivary markers of inflammation (excluding lower sCD40L) were found in individuals with obesity. The salivary marker sCD40L seems to be the best to discriminate obesity, regardless of patients' sex (the highest AUC [area under the curve] values among tested markers), with the determined optimal cut-off point below 3.28 pg/ml. CONCLUSIONS Obesity can cause increased levels of selected inflammatory markers in saliva. The determined discriminatory values may assist in diagnosis of metabolic diseases.Oxygen and glucose deprivation (OGD)-re-oxygenation (OGDR) stimulation to the human endometrial cells mimics ischemia-reperfusion injury. Cyclophilin D (CypD)-dependent programmed necrosis pathway mediates OGDR-induced cytotoxicity to human endometrial cells. We here identified a novel CypD-targeting miRNA, microRNA-1203 (miR-1203). In T-HESC and primary human endometrial cells, ectopic overexpression of miR-1203, using a lentiviral construct, potently downregulated the CypD 3'-untranslated region (3'-UTR) activity and its expression. Both were however upregulated in endometrial cells with forced miR-1203 inhibition by its anti-sense sequence. Functional studies demonstrated that ectopic miR-1203 overexpression in endometrial cells alleviated OGDR-induced programmed necrosis, inhibiting mitochondrial CypD-p53-adenine nucleotide translocator 1 association, mitochondrial depolarization, reactive oxygen species production, and medium lactate dehydrogenase release. Contrarily OGDR-induced programmed necrosis and cytotoxicity were intensified with forced miR-1203 inhibition in endometrial cells. Significantly, ectopic miR-1203 overexpression or inhibition failed to change OGDR-induced cytotoxicity in CypD-knockout T-HESC cells. Furthermore, ectopic miR-1203 overexpression was unable to protect T-HESC endometrial cells from OGDR when CypD was restored by an UTR-depleted CypD construct. Collectively, these results show that miR-1203 targets and silences CypD to protect human endometrial cells from OGDR.Graves' ophthalmopathy is the most common extra-thyroid manifestation in patients with Graves' disease, based on inflammatory and autoimmune conditions in orbital tissue. This practical guideline was formed by a multidiciplinary team, and is intended to provide guidance for diagnosis and management of Graves' ophthalmopathy in daily clinical practice to improve quality of care and treatment outcome.BACKGROUND liver cancer is currently the second deadliest cancer in the world with hepatocelullar carcinoma (HCC) being the commonest form-accounting 90% of all its cases. With the current global alarming increase of obesity, there is hence an increase of fatty liver disease cases, which is one of the major non-viral etiology of cirrhosis in the world. The objective of this study is to evaluate whether obese HCC patients have worse survival outcome. METHODS PubMed, Cochrane, Scopus, ProQuest, and EBSCOhost were comprehensively searched for systematic review and cohort prognostic researches studying overall survival of HCC patients who are underweight and obesity according to their BMI. Three studies were selected and critically appraised. Data were then summarized descriptively. RESULTS the three studies included consist of one meta-analysis and two cohort studies. Meta-analysis study stated no association between overweight and obesity status with higher mortality rate in Asian race HCC patients (aHR, 1.10; 95% CI, 0.