https://www.selleckchem.com/products/hg6-64-1.html 04) p less then 0.0001] and strong opioid use [HR 2.11 (1.64,2.71) p less then 0.001] compared to normal BMI. This association was partially explained by greater comorbidity, pain, and disability in obese groups. The attributable risk for obesity was 15% of overall opioid use and 24% of strong opioid use. Conclusions Obesity is associated with a substantially higher risk of incident chronic opioid use. Approximately 1 in 4 cases of incident use of strong opioids may be attributable to obesity, suggesting a major public health impact. Interventions to prevent or reduce obesity could have an important impact on the use of opioids.Working with suicidal clients is frequently referred to as one of the most demanding and anxiety-provoking aspects of therapeutic work. The aim of this study was to obtain an in-depth understanding of therapists' experience in treating suicidal individuals and to develop a theoretical model of it. Eleven psychotherapists (four men and seven women) participated in individual semistructured interviews. The interviews were audiotaped, transcribed and analysed by the principles of grounded theory. We developed a model of dynamic balance in therapists' experiences and views on working with suicidal clients. The model includes six core themes, which represent aspects of therapists' experience and views where a dynamic balance is needed between two different poles. The core themes are as follows (i) understanding of suicidality the general versus specific; (ii) the role of alliance protective factor versus no guarantees; (iii) attitudes acceptant versus life-oriented; (iv) emotional response worry versus trust; (v) responsibility therapist's professionality versus client's autonomy; and (vi) focus suicidality versus individual as a person. The model takes into account other variables that are relevant to the process and outcomes of the therapy factors, related to the therapist and the client, as wel