Purpose An impoverished production of routinized expressions, namely, formulaic language, has been reported for monolingual speakers with Parkinson's disease (PD). Little is known regarding how formulaic expressions might be manifested in individuals with neurological damage who speak more than one language. This study investigated the processing of formulaic language across first language (L1) and second language (L2) in bilingual individuals with PD. Method Eleven Korean-English bilingual speakers with PD, who acquired Korean as L1 and English as L2, were recruited for this study. Two matched control groups composed of 11 healthy Korean-English bilingual individuals and 11 healthy native English speakers were included for comparison. Their performance on three structured tasks (comprehension, completion, and judgment-correction) and conversational speech was measured and compared across groups for analyses. Results The bilingual speakers with PD had significantly impaired comprehension of formulaic language in L1 and had lower proportions of formulaic expressions in their L1 conversational speech compared with the bilingual controls. Regarding L2, both bilingual groups with and without PD were comparable in their English performance across all tasks. Both groups performed significantly poorer in L2 structured tasks than the native English speakers. Spontaneous production of formulaic language in English (L2 for bilingual individuals) was similar across all three groups. Conclusions The results of this study contribute to the growing body of literature on impoverishment of formulaic language production following subcortical dysfunction. Additionally, findings here demonstrate a selective impairment of formulaic language performance in L1 but not L2 for bilinguals with PD, further supporting the role of the basal ganglia in native language.
  Colorectal cancer (CRC) incidence rates are increasing among individuals < 50 years of age (early-onset CRC) globally with causes unknown. Racial/ethnic disparities in early-onset CRC have also grown more pronounced, because Black individuals have higher early-onset CRC incidence and poorer survival compared with White individuals. We describe the prevalence and burden of early-onset CRC among Africans in Nigeria and African Americans (AAs) in the United States.
 
  We identified Black individuals diagnosed with a first primary CRC ages 18 to 49 years between 1989 and 2017 at Ahmadu Bello University Teaching Hospital in Zaria, Nigeria (Nigerians), and in the United States (AAs) using the National Institutes of Health/National Cancer Institute's SEER program of cancer registries. Multivariable logistic regression models were used to investigate clinical and demographic differences between Nigerians and AAs with early-onset CRC, adjusted for age, sex, tumor site, and histology.
 
  A total of 5,019 Black individuals harbor distinct features of early-onset CRC. Additional investigation of the histopathologic and biologic heterogeneity of early-onset CRCs among Black individuals is critical for understanding racial disparities in susceptibility and outcomes, which may have implications for tailored early-onset CRC prevention, detection, and treatment strategies.Objectives To compare the clinical characteristics and outcomes of patients hospitalized with respiratory syncytial virus (RSV), human metapneumovirus (hMPV), and influenza infections. Methods This study prospectively enrolled 594 patients hospitalized with influenza-like illness (ILI) and laboratory-confirmed RSV, hMPV, or influenza infections over three consecutive influenza seasons at a tertiary hospital in China. Results While certain clinical features were of value as predictors of infection type, none exhibited good predictive performance as a means of discriminating between these three infections (area under the receiver-operating characteristic curve less then 0.70). After controlling for potential confounding variables, RSV infections in pneumonia patients were found to be associated with a 30-day mortality risk comparable to that of influenza patients [odds ratio (OR) 1.016, 95% confidence interval (CI) 0.267-3.856, p = 0.982], whereas hMPV infection was associated with a reduced risk of mortality (OR 0.144, 95% CI 0.027-0.780, p = 0.025). Among those without pneumonia, the 30-day mortality risk in patients with influenza was comparable to that in patients infected with RSV (OR 1.268, 95% CI 0.172-9.355, p = 0.816) or hMPV (OR 1.128, 95% CI 0.122-10.419, p = 0.916). Conclusion Disease severity associated with these three types of viral infection was inconsistent when comparing patients with and without pneumonia, highlighting the importance of etiologic testing.We aimed to investigate the contribution of irisin in the neuroprotective process of exercise training in diabetic rats.  https://www.selleckchem.com/products/zeocin.html  Serum irisin levels, thermal and mechanical pain thresholds and intracellular calcium ([Ca2+]i) levels in sensory neurons were measured at different time intervals during the eight weeks of exercise sessions for the control, non-exercise diabetics (3 groups) and exercise performing (low and high intensity groups) diabetic rats (n = 7-10 for all groups). Non-exercise diabetic groups were treated with irisin in different doses (1, 10 and 20 µg/kg respectively). Recovered pain thresholds at the end of the exercise sessions (p  .05) obtained from experiments. Furthermore, irisin injection decreased the thermal pain threshold of diabetics only at 60th minutes (p  less then  .05). Irisin may have a role in the neuroprotective effect of exercise training.The presence of norfloxacin antibiotic (NFX) in drinking water raises significant scientific concern due to the health and environmental problems that may cause. This study aimed to evaluate the NFX removal 1) in batch adsorption at different pH values on montmorillonite (M) and montmorillonite-carbon hybrids (M-HC); 2) in continuous columns experiments, to assess the technological application of these hybrids as domestic filters, using one M-HC as adsorbent material ranging from 1% to 5%. Batch experiments showed that adsorption occurred in all the samples, being M the material with the highest adsorption capacity (95% of adsorption for cationic NFX). For the M-HC the adsorption seemed to be not strongly dependent of the pH (20%- 41% of adsorption). The characterization of adsorbents and NFX adsorption products (FTIR, XRD, and zeta potential analysis) disclosed that adsorption occurs at both the external surface and the interlayer space of M. For the M-HC synthesized without activation, the interlayer space seemed to be predominantly responsible; while for the activated M-HC the adsorption occurred at the external surface (its interlayer was destroyed).