Continuous joint angle estimation based on a surface electromyography (sEMG) signal can be used to improve the man-machine coordination performance of the exoskeleton. In this study, we proposed a time-advanced feature and utilized long short-term memory (LSTM) with a root mean square (RMS) feature and its time-advanced feature (RMSTAF; collectively referred to as RRTAF) of sEMG to estimate the knee joint angle. To evaluate the effect of joint angle estimation, we used root mean square error (RMSE) and cross-correlation coefficient ρ between the estimated angle and actual angle. We also compared three methods (i.e., LSTM using RMS, BPNN (back propagation neural network) using RRTAF, and BPNN using RMS) with LSTM using RRTAF to highlight its good performance. Five healthy subjects participated in the experiment and their eight muscle (i.e., rectus femoris (RF), biceps femoris (BF), semitendinosus (ST), gracilis (GC), semimembranosus (SM), sartorius (SR), medial gastrocnemius (MG), and tibialis anterior (TA)) sEMG signals were taken as algorithm inputs. Moreover, the knee joint angles were used as target values. The experimental results showed that, compared with LSTM using RMS, BPNN using RRTAF, and BPNN using RMS, the average RMSE values of LSTM using RRTAF were respectively reduced by 8.57%, 46.62%, and 68.69%, whereas the average ρ values were respectively increased by 0.31%, 4.15%, and 18.35%. The results demonstrated that LSTM using RRTAF, which contained the time-advanced feature, had better performance for estimating the knee joint motion.To date, the only available treatment for celiac disease (CD) patients is a life-lasting gluten-free diet (GFD). Lack of adherence to the GFD leads to a significant risk of adverse health consequences. Food cross-contamination, nutritional imbalances, and persistent gastrointestinal symptoms are the main concerns related to GFD. Moreover, despite rigid compliance to GFD, patients struggle in achieving a full restoring of the gut microbiota, which plays a role in the nutritive compounds processing, and absorption. Pivotal studies on the supplementation of GFD with probiotics, such as Bifidobacterium and Lactobacilli, reported a potential to restore gut microbiota composition and to pre-digest gluten in the intestinal lumen, reducing the inflammation associated with gluten intake, the intestinal permeability, and the cytokine and antibody production. These findings could explain an improvement in symptoms and quality of life in patients treated with GFD and probiotics. On the other hand, the inclusion of prebiotics in GFD could also be easy to administer and cost-effective as an adjunctive treatment for CD, having the power to stimulate the growth of potentially health-promoting bacteria strains.  https://www.selleckchem.com/products/mi-3-menin-mll-inhibitor.html  However, evidence regarding the use of prebiotics and probiotics in patients with CD is still insufficient to justify their use in clinical practice.Over last few years, polyurethane (PU) has been applied in a number of areas because of its remarkable features, such as excellent mechanical strength, good abrasion resistance, toughness, low temperature flexibility, etc. More specifically, PU can be easily "tailor made" to meet specific demands. This structure-property relationship endows great potential for use in wider applications. With the improvement of living standards, ordinary polyurethane products cannot meet people's growing needs for comfort, quality, and novelty. This has recently drawn enormous commercial and academic attention to the development of functional polyurethane. Among the major applications, PU is one of the prominent retanning agents and coating materials in leather manufacturing. This review gives a summary of academic study in the field of functional PU as well as its recent application in leather manufacture.The aim of the present study was to ascertain whether an Allium spp. extract rich in organosulfur compounds, such as propyl thiosulfonate (PTSO), added to the feed of growing-finishing pigs at 5 g/kg enhances growth performance or affects the fecal microbiome, the levels of short-chain fatty acids, or the antioxidant capacity of the animals. Fifty male growing pigs (large white) of 23.07 ± 2.87 kg average body weight were randomly allotted to two treatments in a 103-day trial. The trial was divided into two periods, an initial growing phase (56-days) and a finishing phase (47-days). Two dietary treatments for each phase (growing and finishing) were used a control diet (CON) and an experimental diet consisting of the control diet to which 5 g/kg of Allium spp. extract was added to substitute sepiolite (GAR). Throughout the study, body weight, average daily gain (kg/day, ADG), feed intake (kg/day), and feed conversion ratio (kg/kg) were measured, while the backfat thickness and muscle depth were determined at txidant capacity and the cupric reducing antioxidant capacity levels in serum were significantly higher in the same pigs on day 103 than on day 0. Consequently, based on the current results, Allium spp. extract rich in organosulfur compounds, added to the diet at 5 g/kg, had a beneficial effect on the microbiota and would seem to be a possible alternative for increasing the growth performance of growing-finishing pigs. However, further studies on the effects of Allium spp. supplementation on carcass quality are necessary.Pharmaceutical care is a concept which has moved the pharmacy profession from their primary focus on the product to optimising drug therapy for the individual patient. Expanded pharmacy practice beyond pharmaceutical care will further challenge the role perceptions that other health professionals have about pharmacists. Role theory as a philosophical perspective was used to explore rural and remote health professionals' beliefs on pharmacists expanding their clinical role by conducting twenty-three semi-structured interviews. Five role theory categories described the data, role ambiguity, role conflict, role overload, role identity and role insufficiency. The health professionals interviewed were found to be uncertain about the boundaries between the traditional roles of the pharmacist compared to that of the expanded roles. A perceived lack of accountability by pharmacists was seen as a major contributor to role conflict, which in turn was found to impact the ability of pharmacists and other health professionals to work collaboratively.