Although, cannabis users call these substances "cannabis", synthetic cannabinoids have different pharmacological properties, which make them dangerous substances leading to more serious complications. Physicians dealing with cannabis users should be aware of these differences between vegetal cannabis and synthetic cannabinoids.Novel insight into suicidal behavior. This article presents four short examples of new insights into suicidal acts and innovative treatments. These include the results of cognitive neuroscience studies that have identified hypersensitivity to rejection, exclusion, and injustice signals in suicide attempters, as well as persisting trend for risky choices and insufficient cognitive control. These processes may be future therapeutic targets. Moreover, several studies showed on early suicidal trajectories, as well as residual epigenetic scars, as a result of childhood abuse. The people who were victims of these events may require specific intervention. In addition, artificial intelligence is a source of hope to account for the etiological and phenotypic complexity of suicidal behavior, and to establish more precise algorithms of medical decision-making. Ethical issues are raised at the same time. Finally, ketamine is today an innovative treatment (pending authorization) for the rapid reduction of suicidal ideation and a more effective crisis management.Collective measures to prevent suicide. Suicide is a preventable death that requires the implementation of individual and collective preventive actions. A simple and effective action is to limit the access to lethal means. School-based outreach programs reduce suicide attempts. The detection and management of depression by general practitioners plays an important role in suicide prevention. Furthermore, maintaining contact with people at high suicidal risk is a very promising method to prevent suicide.Suicide prevention after a suicide attempt how to stay in touch? Attempted suicide is a major risk factor of further re-attempts and death. Self-harm behaviors are related to multiple causes, explaining why it is ineffective to have a single and simple strategy to offer after the clinical assessment in reducing morbidity and mortality. Furthermore, treatment adherence is known to be especially poor, in a context where social connection seems compromised and source of pain. Effective interventions can be divided into two categories intensive intervention programs (care at home, supported by a series of brief psychotherapy interventions) and, case management programs that rely on a "stay in contact" dimension(letters, telephone, sms, mail, etc.). A prevention algorithm was further proposed to routine care in 2015, in the northern departments of France, Nord et Pas-de-Calais (4.3 million people), taking the name of VigilanS. The inclusion consists in sending a form for every patient assessed after a suicide atteso needed to take care of all the technical aspects of the organization. We measured the evolution of the number of suicide attempts before and after implantation of VigilanS we found an acceleration of the reduction of stay for suicide attempt in Nord et Pas-de-Calais after 2014(-16% instead of -6%), instead of the two Picardy departments the most comparable show a degradation of the phenomenon (+13%). The system is currently being deployed across France.Identifying and taking care of the suicidal risk the concern for others. The suicidal crisis is a period of rupture in the existence of an individual, marked by psychic suffering and tension, the major risk of which being suicide. The diagnostic and therapeutic intervention of the clinician can be made complex by the clinical presentation specific to each individual and the ambivalence of these patients. In this article, we propose ways to identify and evaluate the suicidal crisis, with semio logical elements, and criteria for assessing risk, urgency and dangerousness (RUD). We also provide support for the assessment of the suicidal crisis, with the notions of respect, listening, understanding, and questions to bein cluded in the evaluation of suicidal thoughts and intentions. These elements must make it possible to rigorously evaluate the suicide potential and to help the therapeutic decision, in order to bring the most adapted intervention to these patients.Current modeling of suicidal behavior crisis, transition, and vulnerability. Suicidal behavior is multifactorial and polymorphic. Modeling - although simplifying - is necessary. This article presents three interactive processes the suicidal crisis, the transition from ideas to action, and the suicidal vulnerability. The suicidal crisis is a state of rupture of the psychic balance, often occurring in response to an event of social and interpersonal character, and leading the individual to the significant thoughts that only suicide is the solution to one's own problems. This crisis is particularly marked by an unbearable psychic pain whose cessation is the goal of most suicidal gestures. The acting out occurs in less than a quarter of people with suicidal ideas. The mechanisms responsible for the emergence of suicidal ideation appear partly different from those allowing the transition to a suicidal act. Suicidal risk in a context of psychosocial stress is increased by the existence of vulnerability factors, whose complex nature is developmental, genetic, cognitive, and temperamental, among others.Suicidal behaviors in France still a public health issue. In 2015, 9,109 deaths by suicide were counted in France, representing 13.7 suicides per 100,000 inhabitants. This rate has been declining for 30 years as in many countries. A significant underestimation is however suggested for various reasons. The risk of suicide is three times higher for men than for women. Suicide rates increase among those over 75 years of age, mostly for men, while the highest suicide frequencies are found among those aged 35-65, and suicide is the second leading cause of death among adolescents and young adults. More than half of suicides are by hanging. Suicide attempts are 10 to 20 times more frequent than suicide, about 100 to 200,000 acts each year, and are also decreasing over the last years.  https://www.selleckchem.com/products/Eloxatin.html  In 2017, 88,712 hospitalizations for suicide attempts were recorded in France. Suicide attempts are associated with an increased risk of death, by suicide in particular, but also by somatic disease. The prevalence of suicidal ideation, appreciated through surveys in the general population, is high, estimated at about 5%.