https://www.selleckchem.com/products/cd532.html 016), maternal dissatisfaction with labor (p=.038) and formula feeding in the hospital (p<.001) or at the end of the 1st month postpartum (p<.001) are associated with the occurrence of breastfeeding difficulties. Also, the mothers who experienced lactation mastitis (p=.009), had sleep difficulties (p=.013), woke up fatigued (p<.001) during the first 6 weeks postpartum, and the mothers whose infants experienced colic (p=.009) were more likely to complain about breastfeeding difficulties at the 6th week postpartum. This study demonstrates a relationship between increased scores on maternal psychometric tools in the perinatal period and other perinatal factors with increased breastfeeding difficulties at the 6th weeks postpartum. This study demonstrates a relationship between increased scores on maternal psychometric tools in the perinatal period and other perinatal factors with increased breastfeeding difficulties at the 6th weeks postpartum. Depression is a common mental disorder and represents a global mental health concern. Presents with depressed mood, loss of interest or pleasure, feelings of guilt or low self-worth, disturbed sleep or appetite, low energy and poor concentration. Epidemiologic research have found clear genders differences in the prevalence of Major depressive disorders (MDD). The aim of this study was to find the difference in the symptoms of Major depressive disorder (MDD) between genders. It was analyzed 92 subjects from Health Center Zivinice in the period from September 2019 to May 2021, of which 57 (62 %) are women and 35 (38%) are men. The study identified and measured the severity of 25 different symptoms of depressive disorders in the analyzed subjects. The average age of women is 56 years ± 8.88, and the average age of men is 52 years ± 11.03. Statistical data were analyzed in SPSS statistical program. Comparing the results t tests revealed significant difference between genders in symptoms