https://www.selleckchem.com/products/ijmjd6.html We investigate the optical wavelength dependence of the photoacoustic (PA) signal, detected with bandwidth (BW) in the MHz range, of gold nanospheres (NSs) immersed in water upon illumination with ns laser pulses. We compare the wavelength dependence of the PA signal (within the MHz BW) with the one of the optical absorption coefficient as determined from optical transmission measurements. Thermal boundary conductance (TBC) at the gold-water interface is taken into account, as well as the temperature dependence of the thermal expansion coefficient of water. The effects of NS size and laser pulse duration on the PA signal are also explored. The PA signal is investigated with an opto-thermo-acoustic model considering light absorption in gold NS and in a surrounding water shell. The aim of this study was to evaluate the clinical efficacy of Xuanfei Baidu Decoction (XBD) combined with conventional drug therapy compared with conventional medicine alone in patients with coronavirus disease 2019 (COVID-19). Forty-two patients with COVID-19 were randomly assigned to XBD plus conventional medicine (n=22) and conventional medicine alone (n=20). Both groups were treated for 1 week. The primary endpoint was the disappearance rate of main symptoms (fever, cough, and fatigue). Compared with the conventional medicine, the disappearance rate of clinical symptoms such as fever, cough, fatigue and loss of appetite in the experimental group were significantly reduced (P<0.05). The number of white blood cells and lymphocytes in the experimental group increased significantly (P<0.05), which all returned to normal parameters. Meanwhile, the C-reactive protein and erythrocyte sedimentation rate in the experimental group were significantly reduced (P<0.05). XBD combined with conventional medicine may significantly improve patient's clinical symptoms, increase the number of white blood cells and lymphocytes to improve immunity, and also signi