Actein Antagonizes Common Squamous Cellular Carcinoma Spreading through Triggering FoxO1.
 Positron emission tomography (PET) suffers from limited spatial resolution in current head and neck cancer management. We are building a dual-panel high-resolution PET system to aid the detection of tumor involvement in small lymph nodes ( less then 10 mm in diameter). The system is based on cadmium zinc Telluride (CZT) detectors with cross-strip electrode readout (1 mm anode pitch and 5 mm cathode pitch). One challenge of the dual-panel system is that the limited angular coverage of the imaging volume leads to artifacts in reconstructed images, such as the elongation of lesions. In this work, we leverage a penalized maximum-likelihood (PML) reconstruction for the limited-angle PET system. The dissimilarity between the image to be reconstructed and a prior image from a low-resolution whole-body scanner is penalized. An image-based resolution model is incorporated into the regularization. Computer simulations were used to evaluate the performance of the method. Results demonstrate that the elongation of the 6-mm and 8-mm diameter hot spheres is eliminated with the regularization strength being 0.02 or larger. The PML reconstruction yields higher contrast recovery coefficient of hot spheres compared to the maximum-likelihood reconstruction, as well as the low-resolution whole-body image, across all hot sphere sizes tested (3, 4, 6, and 8 mm). The method studied in this work provides a way to mitigate the limited-angle artifacts in the reconstruction from limited-angle PET data, making the high-resolution dual-panel dedicated head and neck PET system promising for head and neck cancer management. Creative Commons Attribution license.Co(OH)2 nanosheets/Cu(OH)2 nanorods (Co(OH)2 Nss/Cu(OH)2 Nrs) composite electrode for non-enzymatic glucose sensing was fabricated by electrodepositing Co(OH)2 Nss on Cu(OH)2 nanorods substrate grown directly on the copper sheet via a simple one-step reaction. The Co(OH)2 Nss/Cu(OH)2 Nrs composite electrode was characterized by scanning electron microscopy, energy dispersive X-ray spectroscopy, X-ray diffraction, X-ray photoelectron spectroscopy. The performance of glucose sensing of the composite electrode was investigated by cyclic voltammetry and chronoamperometry. The composite electrode shows high sensitivity of 2254.2 µA mM-1 cm-2 up to 2 mM with a lower detection limit of 73 nM (S/N = 3). The composite electrode is highly selective to glucose in the presence of various substances always co-existed with glucose in real blood samples. The response of the composite towards human blood serum was in good agreement with that of commercially available glucose sensors, suggesting that a promising electrode material for highly sensitive and selective non enzymatic sensing of glucose can be envisioned. © 2020 IOP Publishing Ltd.OBJECTIVE Early detection and timely management of bleeding is critical as failure to recognize physiologically significant bleeding is associated with significant morbidity and mortality. Many such instances are detected late, even in highly monitored environments, contributing to delay in recognition and intervention.  https://www.selleckchem.com/EGFR(HER).html  We propose a non-invasive early identification model to detect bleeding events using continuously collected photoplethysmography (PPG) and electrocardiography (ECG) waveforms. APPROACH Fifty-nine York pigs undergoing fixed-rate, controlled hemorrhage were involved in this study and a Least Absolute Shrinkage and Selection Operator (LASSO) regression-based early detection model was developed and tested using PPG and ECG derived features. The output of the early detection model was a risk trajectory indicating the future probability of bleeding. MAIN RESULTS Our proposed models were generally accurate in predicting bleeding with an area under the curve of 0.89 (95% CI 0.87-0.92) and achieved the average time of 16.1 mins to detect 16.8% blood loss when a false alert rate of 1% was tolerated. Models developed on non-invasive data performed with similar discrimination and lead time to hemorrhage compared to models using invasive arterial blood pressure as monitoring data. SIGNIFICANCE A bleed detection model using only non-invasive monitoring performs as well as those using invasive arterial pressure monitoring. © 2020 Institute of Physics and Engineering in Medicine.A mathematical model of the crystallization process in a thin film is presented with the purpose to overcome the limitations of Kolmogorov-Johnson-Mehl-Avrami theory regarding finite-size systems. Two ways of nucleation are taken into account at the film boundaries and in the bulk. The solution is obtained in terms of crystallization probability, which is the probability of a point inside the film to be included in the crystal at a given moment of time. It is shown that the characteristic feature of crystallization in finite-size systems is a non-uniform distribution of crystalline fraction. © 2020 IOP Publishing Ltd.RhSn is a topological semimetal with chiral fermions. At ambient pressure, it exhibits large positive magnetoresistance (MR) and field-induced resistivity upturn at low temperatures.  https://www.selleckchem.com/EGFR(HER).html  Here we report on the electrical transport properties of RhSn single crystal under various pressures. We find that with increasing pressure the temperature-dependent resistivity (T) of RhSn varies minutely, whereas the value of MR at low temperatures decreases significantly. The (T) data was fitted with the Bloch-Grüneisen model and the Debye temperature was extracted. Analyses of the nonlinear Hall conductivity with two-band model indicate that the carrier concentrations do not change significantly with pressure, but the mobilities for both electron and hole carriers are reduced monotonically, which can account for the significant reduction of MR under high pressures. © 2020 IOP Publishing Ltd.Polyethylenimine (PEI), a kind of cationic non-viral gene delivery vector, is capable of stable and efficient transgene expression for gene delivery. However, low transfection efficiency in vivo along with high toxicity limited the further application of gene therapy in the clinic. To enhance gene transfection performance and reduce cytotoxicity of polyethylenimine, branched polyethylenimine-derived cationic polymers BPEI25k-man-S/L/M/H with different grafting degree with mannitol moieties were prepared and the transfection efficiency was evaluated. Among them, BPEI25k-man-L showed the best transfection efficiency, lower toxicity, and significantly enhanced long-term systemic transgene expression for 96 hours in vivo even at a single-dose administration. The results of cellular uptake mechanism and western-blot experiments revealed that the mannitol modification of BPEI25k induced and up-regulated the phosphorylation of caveolin-1 and thus enhanced the caveolae-mediated cellular uptake. This class of gene delivery system highlights a paradigmatic approach for the development of novel and safe non-viral vectors for gene therapy.