Mortality at 1-year was 41.6%, and neurological injury at discharge was observed in 44.1% of individuals. In the multivariate analysis, tachycardia after resuscitation was an independent predictor of both 1-year mortality (hazard ratio, 2.66; 95% CI 1.20-5.85; P=0.03) and neurological injury at discharge (odds ratio, 2.65; 95% CI 1.27-5.55; P=0.04). CONCLUSIONS In patients who recovered from OHCA due to ACS, tachycardia after resuscitation predicted poor clinical outcome.A considerable proportion of shift workers have work schedule-related insomnia and/or excessive sleepiness, a phenomenon described as shift work disorder (SWD). There is yet a lack of evidence on whether or not employees recover from symptoms of SWD between work shifts. We studied whether SWD and its subtypes are associated with insomnia and excessive sleepiness during weekly non-work days and with 24-h sleep time. Hospital employees answered a survey on SWD, insomnia and excessive sleepiness on weekly non-work days, and 24-h sleep. To identify shift workers with night shifts (n=2,900, 18% with SWD) and SWD, we linked survey responses to employers' register on working hours. SWD included three subtypes insomnia only (SWD-I, 4%, n=102), excessive sleepiness only (SWD-Es, 8%, n=244), and both insomnia and excessive sleepiness (SWD-IEs, 6%, n=183). Based on regression analyses, SWD was associated with excessive sleepiness on non-work days (OR 1.42, 95% CI 1.07-1.88) and with insomnia on non-work days (0.53, 0.31-0.91).  https://www.selleckchem.com/products/Cytarabine(Cytosar-U).html  SWD-I was associated with excessive sleepiness on non-work days (2.25, 1.31-3.87) and with shorter sleep (7-7.5h 1.96, 1.06-3.63; ≤6.5h 2.39, 1.24-4.59; reference ≥8h). The results suggest that especially employees with SWD-I may need longer time to overcome excessive sleepiness than allowed by their roster.BACKGROUND Complete blood cell count (CBC)-derived inflammatory biomarkers are widely used as prognostic parameters for various malignancies, but the best predictive biomarker for early-stage non-small-cell lung cancer (NSCLC) is unclear. We retrospectively analyzed early-stage NSCLC patients to investigate predictive effects of preoperative CBC-derived inflammatory biomarkers. PATIENTS AND METHODS We selected 311 consecutive patients with pathological stage IA NSCLC surgically resected from April 2006 to December 2012. Univariate and multivariate Cox proportional analyses of recurrence-free survival (RFS) were used to test the preoperative systemic immune inflammation index (SII), neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR), and monocyte-lymphocyte ratio (MLR). RESULTS Preoperative high MLR levels were significantly associated with patient sex, smoking status, and postoperative recurrence (p 2 cm had significantly shorter RFS than other subgroups (p = 0.0289). CONCLUSIONS The preoperative MLR level is the optimal predictor of recurrence in patients with pathological stage IA NSCLC.PURPOSE The diagnostic potential of conventional multi-planar reconstruction (MPR) images, which consist of horizontal, frontal, and sagittal section, in approximating the anatomical distance between tumors and intersegmental planes remains unclear. The aim of the present study was to clarify the validity of decision-making for segmentectomy based on MPR imaging and identify a specific tumor location that is likely to result in the overestimation of the anatomical margin on MPR images. METHODS The study population included 33 patients who were considered eligible for segmentectomy based on the observation of MPR images, and verified using a commercially available image-analysis software whether the decision-making based on MPR images was indeed correct or not. RESULTS MPR image-based assessment resulted in the overestimation of the anatomical margin in as many as 8 (24%) of the 33 patients. Overestimation predominantly occurred in cases involving patients with tumors at certain segments (right S1, right S2, right S3, left S3, and left S4) that had a complex and oblique intersegmental plane. CONCLUSION Conventional MPR image-based assessment frequently resulted in the overestimation of the anatomical margin. We recommend using software-based assessment preoperatively in patients with tumors in the risky segments, particularly in cases involving indistinct tumors.BACKGROUND Studies on alexithymia have been primarily targeted at adult populations. Although some recent studies on alexithymia have focused on children and young adolescents, the literature is not entirely sufficient to develop an assessment tool. The aim of this study was to develop a new scale to measure alexithymia-like features in young adolescents and to evaluate its psychometric properties. METHODS A total of 1,444 Japanese junior high school students (701 males, 743 females, aged 12-15, mean age = 13.37 years, SD = 0.98) participated in two surveys conducted at their own schools. RESULTS First, exploratory factor analysis (EFA) with the first survey data (n=981) demonstrated that this new scale had a unifactor structure as a result of the MAP analysis and parallel analysis. Second, confirmatory factor analysis (CFA) with the second survey data (n=463) also verified the unifactor structure of this new scale with acceptable goodness of model fit. The new scale also demonstrated modest internal consistency. CONCLUSIONS As the correlations between this new alexithymia scale and the related variables were significantly small in accordance with our hypothesis, we could demonstrate that this new scale had acceptable reliability and construct validity and could be useful for measuring alexithymic tendency in young adolescents.BACKGROUND As part of the planning for a future multicenter study, this preliminary clinical trial was performed to explore candidate biomarkers useful for predicting the therapeutic effects of sublingual immunotherapy (SLIT) for Japanese cedar pollinosis (JCP) using serum samples from patients. METHODS This prospective study included patients undergoing SLIT for JCP at our hospital. All enrolled patients (n = 17) started SLIT between June and November of 2015. With informed consent from the patients, in January, March, and June of 2016, blood samples were obtained, and an inquiry was conducted using the Japan rhino-conjunctivitis quality of life questionnaire (JRQLQ). Based on the JRQLQ results, we allocated 6 patients with the most favorable results into the high response group (HRG), and 5 patients with the most unfavorable results into the poor response group (PRG). Subsequently, we compared the serum data between the two groups to identify useful biomarkers. RESULTS The IL-12p70 and VEGF levels tended to be higher in the HRG than in the PRG in January, March and June (0.