https://www.selleckchem.com/products/ipi-549.html In both rat and human tissue, pretreatment with the alpha-1 adrenoreceptor antagonist tamsulosin inhibited the response to noradrenaline, whereas the effect of oxytocin was unimpaired. Our data (from men and rodents) strongly suggest that the hormone oxytocin is involved in the ejaculatory process. Thus, oxytocin-based medications might be a promising non-adrenergic treatment option for ejaculatory disorders. Additionally, we propose that S19 could be an advantageous model (detecting very low concentrations of oxytocin) to test the bioactivity of new oxytocin agonists and oxytocin antagonists.In this study, the effects of curcumin, glutathione (GSH), malondialdehyde (MDA) levels, advanced protein oxidation products (AOPP), superoxide dismutase (SOD) and catalase (CAT) activities in experimental liver damage with diethylnitrosamine (DEN) in Swiss albino mice were investigated. Subjects (n = 9) were divided into 5 as tumor control 1, tumor control 2, curcumin preservative and treatment, and healthy controlgroup. Curcumin oral gavage (in 150 mg/kg of ethylalcohol) was given to the protecting group for 19 days, 5 days before the administration of Diethylnitrosamine, and 24 hours after the administration of Diethylnitrosamine. 100 μl of ethylalcohol oral gavage was given to the healthy group for 19 days. While MDA levels decreased significantly in the curcumin preservative group (p 0.05), (p = 0.073). SOD activities increased significantly in both groups. It was found as (p less then 0.05), (p = 0.001) and (p less then 0.05), (p = 0.002), respectively. GSH levels decreased but these reductions were not found statistically significant. CAT activities increased significantly in both groups. It was determined as (p less then 0.05), (p = 0.001) for both groups. The significant CAT activities were found in both the curcumin protective group and the curcumin treatment group AOPP values decreased in curcumin protective group MDA