https://www.selleckchem.com/products/protokylol-hydrochloride.html BACKGROUND Triclosan-coated sutures have been shown to reduce surgical-site infection (SSI) in emergent operation for fecal peritonitis. Barbed sutures provoke a homogeneous distribution of tension throughout the suture, implying better blood supply to the wound edges and healing. The aim of this study was to evaluate the effect, on SSI and evisceration, of using triclosan-coated and barbed sutures for fascial closure in patients undergoing emergent surgery. STUDY DESIGN A prospective, randomized clinical trial was performed. Patients were randomized into 3 groups those undergoing aponeurotic closure with triclosan-coated barbed suture (Stratafix Symmetric [Johnson & Johnson]), patients undergoing closure with triclosan-coated polydioxanone loop suture (PDS plus [Johnson & Johnson]), and patients undergoing closure with polydioxanone loop suture (PDS [Johnson & Johnson]). Primary investigated outcomes were SSI and evisceration rates during a follow-up period of 30 days. The primary analysis plan was based on The use of barbed sutures reduces the incidence of evisceration. BACKGROUND Outcome improvement is a major goal of pancreatic surgery. Such efforts include decreasing perioperative narcotic use to optimize care and reduce potential contributions to the opioid crisis. Ketorolac, a frequent component of opioid-minimizing recovery pathways, has not been universally adopted over concerns regarding adverse events including anastomotic fidelity, hemorrhage, and renal failure. Thus, we examined ketorolac's effects on pancreatic fistula (PF) formation and related morbidity following pancreaticoduodenectomy (PD). STUDY DESIGN A retrospective review of consecutive patients undergoing PD from 12/2008 - 9/2018 was conducted and stratified by receipt of ketorolac during the initial five days post-operatively. The primary outcome was clinically relevant PF (CR-PF) per international consensus definitions. Secon