https://www.selleckchem.com/products/GDC-0449.html should still be offered, based on participant preference. Customising e-consenting platforms may improve accessibility for individuals with specific needs, and increase engagement with study information. Research teams must offer prospective participants opportunities to discuss study information in real-time. E-consent may facilitate remotely-conducted research by offering a feasible and robust alternative to face-to-face consenting approaches, however paper-based options should still be offered, based on participant preference. Customising e-consenting platforms may improve accessibility for individuals with specific needs, and increase engagement with study information. Research teams must offer prospective participants opportunities to discuss study information in real-time. Social media have emerged as a platform for experience and knowledge sharing in the medical community. The online medical community is garnering increasing research attention; however, there is a lack of understanding of what factors influence the helpfulness and engagement of experience sharing in the community. Clinical documents manifest physicians' experience and knowledge. This study fills the knowledge gap by investigating what elements of clinical documents contribute to the helpfulness of sharing clinical documents online and what influence member engagement. Clinical documents follow certain architecture to specify their structure and semantics for exchange (e.g., HL7 C-CDA). Accordingly, the structural elements of clinical documents may influence document helpfulness for the online community. Member engagement is one of the indicators of community success. We collected 6514 clinical documents from a real-world online medical community, and normalized them with the structural elements of HL7 C-CDe quality of medical decisions. The findings provide guide on how to improve the effectiveness of sharing clinical experience online. The n