https://www.selleckchem.com/products/ti17.html The patient, a 70-year-old woman, presented with a mass in the right nasal cavity accompanied by recurrent nosebleeds for 3 months. Physical examination revealed a mass in the right nasal vestibule, with a diameter of about 1.5 cm. The surface of the mass was not smooth and nasal CT showed a mass in the right nasal vestibule, which could be surgically removed. Immunohistochemical results of the tumor showed CKpan（3+）, CK5/6（3+）, p40（3+）, p53（+）, CD10（-）, AR（-）, Bcl-2（-）, ki-67（+20%）. Pathological diagnosis was acantholytic dyskeratotic acanthoma. This disease is rare and easy to be misdiagnosed, so it is necessary to pay attention to identification.ObjectiveTo investigate the correlation between the expression level of serum pituitary tumor transforming gene（PTTG1） and clinicopathological characteristics and prognosis in patients with laryngeal cancer. MethodEnzyme-linked immunosorbent assay was used to detect the expression of serum PTTG1 in 80 patients with laryngeal cancer and 60 patients with vocal cord polyps. The relationship between the clinicopathological characteristics of patients with laryngeal cancer and the expression of serum PTTG1 was analyzed. Cox regression analysis was used to analyze related factors affecting the prognosis of laryngeal cancer. ResultSerum PTTG1 expression level in patients with laryngeal cancer was significantly higher than that in patients with vocal cord polyps, and the difference was statistically significant（P less then 0.05）. The higher the lymph node metastasis, the higher the tumor TNM stage, and the lower the degree of differentiation, the higher the serum PTTG1 expression level（P less then 0.05）. In the prognostic survival analysis, univariate analysis showed that lymph node metastasis, tumor TNM stage, degree of differentiation, tumor diameter, and expression of PTTG1 were related to the prognosis of laryngeal cancer（P less then 0.01）. Cox regression multivariate showed lymp