However, the association disappeared with halving C181n-9t by 2009-2010. In contrast, neither of the ruminant-derived TFAs (C161n-7t and C181n-7t) suggested any inverse correlations with all-cause death, mortality due to heart disease, cancer or other causes.
 
  The major isomer of industrial TFAs, the higher circulating C181n-9t might be associated with increased long-term mortality. The associations with death risk turned slight with the reduction of TFAs consumption by half. However, dietary guidelines should rigorously identify the healthy effect of animal TFAs consumption.
 The major isomer of industrial TFAs, the higher circulating C181n-9t might be associated with increased long-term mortality. The associations with death risk turned slight with the reduction of TFAs consumption by half. However, dietary guidelines should rigorously identify the healthy effect of animal TFAs consumption.
  Our purpose was to analyze influence of sarcopenia on overall survival (OS) in patients with malignant hematological diseases (MHD) based on a large sample.
 
  MEDLINE, EMBASE, and SCOPUS databases were screened for associations between sarcopenia and OS in MHD up to December 2019. Overall, 7 studies met the inclusion criteria. The methodological quality of the involved studies was checked according to the QUADAS instrument. The meta-analysis was undertaken using RevMan 5.3 software.
 
  The included 7 studies comprised 1578 patients. There were different MHD diffuse large B cell lymphoma (DLBCL, 4 studies, 573 patients, 36.3%), acute leukemias and/or myelodysplastic syndrome (2 studies, 949 patients, 60.1%), and multiple myeloma (one study, 56 patients, 3.6%). Sarcopenia identified on CT examinations was reported in 617 patients (39.1%, range, 24.6%-66.1%). In the overall sample, showed that sarcopenia was associated with lower OS (simple regression HR 2.15, CI 95% 1.42-3.25, p<0.0003; multiple regression HR=1.94, CI 95% 1.30-2.90, p<0.001). Furthermore, the role of sarcopenia was analyzed in DLBCL and acute leukemias/myelodysplastic syndrome. In DLBCL, sarcopenia was associated with lower OS (simple regression HR 3.05, CI 95% 2.30-4.05, p<0.00001; multiple regression HR=2.39, CI 95% 1.77-3.22, p<0.00001). In leukemias, sarcopenia was associated with lower OS in simple regression only (simple regression HR 1.57, CI 95% 1.07-2.31, p<0.02; multiple regression HR=1.82, CI 95% 0.92-3.58, p<0.08).
 
  Sarcopenia is an independent predictor of OS in patients with DLBCL underwent chemotherapy.
 Sarcopenia is an independent predictor of OS in patients with DLBCL underwent chemotherapy.
  Consuming 0.10-0.14g essential amino acids (EAA)/kg/dose (0.25-0.30g protein/kg/dose) maximally stimulates muscle protein synthesis (MPS) during energy balance. Whether consuming EAA beyond that amount enhances MPS and whole-body anabolism following energy deficit is unknown. The aims of this study were to determine the effects of standard and high EAA ingestion on mixed MPS and whole-body protein turnover following energy deficit.
 
  Nineteen males (mean±SD; 23±5y; 25.4±2.7kg/m
  ) completed a randomized, double-blind crossover study consisting of two, 5-d energy deficits (-30±4% of total energy requirements), separated by 14-d. Following each energy deficit, mixed MPS and whole-body protein synthesis (PS), breakdown (PB), and net balance (NET) were determined at rest and post-resistance exercise (RE) using primed, constant L-[
  H
  ]-phenylalanine and L-[
  H
  ]-tyrosine infusions. Beverages providing standard (0.1g/kg, 7.87±0.87g) or high (0.3g/kg, 23.5±2.54g) EAA were consumed post-RE. Circulating EAA were measured.
 
  Postabsorptive mixed MPS (%/h) at rest was not different (P=0.67) between treatments. Independent of EAA, postprandial mixed MPS at rest (standard EAA, 0.055±0.01; high EAA, 0.061±0.02) and post-RE (standard EAA, 0.055±0.01; high EAA, 0.065±0.02) were greater than postabsorptive mixed MPS at rest (P=0.02 and P=0.01, respectively). Change in (Δ postabsorptive) whole-body (g/180min) PS and PB was greater for high than standard EAA [mean treatment difference (95% CI), 3.4 (2.3, 4.4); P=0.001 and-15.6 (-17.8, -13.5); P=0.001, respectively]. NET was more positive for high than standard EAA [19.0 (17.3, 20.7); P=0.001]. EAA concentrations were greater in high than standard EAA (P=0.001).
 
  These data demonstrate that high compared to standard EAA ingestion enhances whole-body protein status during underfeeding. However, the effects of consuming high and standard EAA on mixed MPS are the same during energy deficit.
 
  NCT03372928, https//clinicaltrials.gov.
 NCT03372928, https//clinicaltrials.gov.Identifying pulmonary nodules for resection that are small or are deep within the lung parenchyma is a frequently encountered challenge during video-assisted thoracoscopic surgery (VATS). Several image-guided localizing techniques have been described; however, there is limited literature on using these techniques in pediatric patients.  https://www.selleckchem.com/products/Temsirolimus.html  We assessed the feasibility of using a commercially available ethylene-vinyl alcohol polymer (EVOH) as an alternative technique for lung nodule localization prior to VATS. We describe our experience of successful EVOH lung nodule localization in three pediatric patients with an oncologic history presenting with new lung nodules.Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is a form of necrotizing vasculitis with few or no immune deposits. It primarily affects small and medium blood vessels. AAV is classified into three categories, granulomatosis with polyangiitis (GPA), microscopic polyangiitis (MPA) and eosinophilic granulomatosis with polyangitis (EGPA), and two major ANCAs, proteinase 3 (PR3)-ANCA or myeloperoxidase (MPO)-ANCA are involved in their pathogenesis. Intractable otitis media frequently occurs in patients with GPA, MPA or EGPA, although all patients show similar clinical features, regardless of the type of AAV. Furthermore, approximately 15% patients with otitis media caused by AAV do not show ANCA positivity, histopathological evidence, or any other AAV-related lesions at the initial visit; therefore, these patients do not fulfill the ordinary diagnostic criteria for systemic AAV. Thus, we first proposed that this condition could be categorized as "otitis media with AAV (OMAAV)". Subsequently, the Japanese Otological Society (JOS) conducted a nationwide survey between December 2013 and February 2014 and identified 297 patients with OMAAV.