https://www.selleckchem.com/products/apr-246-prima-1met.html Sperm motility within the cauda epididymidis declined significantly after CPF treatment, which was accompanied by a decrease in sperm density, upregulation of relative reactive oxygen species (ROS) levels, and downregulation of glutathione reductase activity. In vitro incubation experiments showed that sperm rapidly lost their capacity for linear movement; the relative ROS levels also increased significantly, while the mitochondrial membrane potential (MMP) showed a significant decrease. However, the integrity of the plasma membrane was not affected by CPF administration. The above data indicated that exposure to CPF reduces sperm motility by disrupting mitochondrial function and increasing the level of oxidative stress during sperm maturation, thereby reducing the fecundity of male mice. The above data indicated that exposure to CPF reduces sperm motility by disrupting mitochondrial function and increasing the level of oxidative stress during sperm maturation, thereby reducing the fecundity of male mice.The families' data damaged by the earthquake and flood in villages and towns along Fujiang River in Sichuan are collected by using intelligences Internet of, and the process and the degree of ruined the production and life of the farmers in this area are evaluated through the information diffusion technology. The villages and towns had suffered a large loss of integrated risk from floods and earthquakes, with an average annual loss of 5.758 million Yuan. Through the comprehensive suppression and blocking intervention combined with the village watershed management and post-disaster reconstruction, the frequency and the degree of disaster occurrence have gradually decreased in the past decades, and the resilience of infrastructure such as regional rivers and diversion canals to resist integrated disasters have been enhanced and the effect of this design scheme of comprehensive disaster prevention and control