https://www.selleckchem.com/products/mivebresib-abbv-075.html The loss of type I and type II cells will also block normal active resorption of alveolar fluid. Subsequent endothelial damage leads to transudation of plasma proteins, formation of hyaline membranes, and an inflammatory exudate, characteristic of ARDS. Repair might be normal, but if the type II cells are severely damaged alternative pathways for epithelial repair may be activated, which would result in some residual lung disease.Background Mesenteric traction syndrome (MTS), which is characterized by arterial hypotension and tachycardia following mesenteric traction (MT), frequently occurs during abdominal surgery. Dexmedetomidine, commonly used in general anesthesia during major surgery, has a sympatholytic effect and attenuates the compensatory response to hypotension. Objective Assess the effect of dexmedetomidine on hypotension following mesenteric traction. Design Prospective, randomized, controlled clinical trial. Setting Department of Anesthesiology, Zhenjiang First People's Hospital in China. Patients and methods Patients were randomly divided into three groups. Dexmedetomidine, 0.5 or 1.0 µg/kg, was intravenously administered over 15 minutes before skin incision followed by a maintenance rate of 0.5 µg/kg/h in groups D1 and D2, respectively; saline was administered in group C. Main outcome measure(s) The duration of hypotension, heart rate and plasma norepinephrine level in patients with MTS were recorded within 60 minutes following MT. Sample size 75 patients. Results The duration of hypotension in the MTS patients in group D1 and D2 was significantly longer than that in groups C (D1 vs. C, P less then .05; D2 vs. C, P less then .01). Significantly more phenylephrine was required to treat hypotension in group D1 and D2 than was required for patients in group C (P less then .05). The increase in heart rate during the first 15 minutes of MT in group D2 was significantly attenuated compared to tha