https://www.selleckchem.com/products/Y-27632.html Based on the laccase-mimicking activity of Cu2+-modified University of Oslo (UiO) metal-organic framework (UiO-67-Cu2+), we developed a colorimetric sensor array for distinguishing a series of phenols with different number and position of substituted hydroxyl group (-OH) and different substituent group on the benzene ring, including phenol, catechol, quinol, resorcinol, pyrogallol, phloroglucinol, o-chlorophenol, o-aminophenol, and o-nitrophenol. The highest occupied molecular orbital (HOMO) and lowest unoccupied molecular orbital (LUMO) energy levels of phenolic compounds were obtained by theoretical calculation. The results show that the lower the LUMO energy level, the easier the chromogenic reaction occurs. The UiO-67-Cu2+-catalyzed phenol chromogenic reaction showed a good linearity in the range from 0.1 to 200 μM with limit of detection approximately 61 nM. Through the detection of phenol in tap water and river water, the recovery rate and RSD (n = 3) were calculated as 94.1~103% and 1.0~3.3, respectively, showing good recovery, reliable results, and outstanding stability. Therefore, the proposed colorimetric sensor array will have a great potential for the detection of phenols in the environment. Schematic presentation of a simple and sensitive colorimetric strategy based on the laccase-mimicking activity of Cu2+-modified UiO-type metal-organic framework (MOFs, Uio-67-Cu2+) to distinguish phenols with analogous structures.The molecular structure, UV-visible spectra, and optical properties of D-π-A conjugated organic dye molecules (Disperse Red 1 (DR1) and Disperse Red 73 (DR73)) were analyzed using density functional theory (DFT) and time-dependent density functional theory (TD-DFT) and compared with azobenzene molecule to study the effect of donor and acceptor substituents on the molecular properties. The performance of DFT functionals is investigated using B3LYP hybrid functional and three long-range correct