e., what we think others think of an agent) and (b) co-mentalizing mentalizing about an agent in conjunction with others' mentalizing of that agent (i.e., conforming to others beliefs about another agent's internal states). The weights of these four elements is determined by metacognitive insight and confidence in one's own or another's mentalizing ability, yielding a dynamic interaction between these circuits. To advance our knowledge on mentalizing during live social interaction, we identify how these subprocesses can be organized by different target agents and facilitated by combining computational modeling and interactive brain approaches. People spend considerable time within built environments. In this study, we tested two hypotheses about the relationship between people and built environments. First, aesthetic responses to architectural interiors reduce to a few key psychological dimensions that are sensitive to design features. Second, these psychological dimensions evoke specific neural signatures. In Experiment 1, participants (n = 798) rated 200 images of architectural interiors on 16 aesthetic response measures. Using Psychometric Network Analysis (PNA) and Principal Components Analysis (PCA), we identified three components that explained 90% of the variance in ratings coherence (ease with which one organizes and comprehends a scene), fascination (a scene's informational richness and generated interest), and hominess (extent to which a scene reflects a personal space). Whereas coherence and fascination are well-established dimensions in response to natural scenes and visual art, hominess emerged as a new dimension related to architectur. Furthermore, valuation of architectural processing in visual cortices varies by dimension and task. Polycyclic aromatic hydrocarbons (PAH) mainly originate from incomplete combustion of organic materials and are, among other sources, found in traffic emissions, smoked or barbecued food, leafy vegetables, and tobacco smoke. Some PAH or their metabolites are hazardous for health and classified as carcinogenic, mutagenic, or toxic to reproduction. Urine samples from 3- to 17-year-old children and adolescents living in Germany were analysed for concentrations of metabolites of the PAH fluorene, naphthalene, phenanthrene, and pyrene in the population-representative German Environmental Survey for Children and Adolescents GerES V (2014-2017). PAH metabolites were analysed in urine samples of 516 participants and could be quantified in 88-100% of the samples. Geometric mean concentrations were 0.785 μg/L (0.688 μg/gcreatinine) for 1-OH-naphthalene, 4.233 μg/L (3.706 μg/gcrea) for 2-OH-naphthalene, 0.139 μg/L (0.122 μg/gcrea) for 1-OH-phenanthrene, 0.085 μg/L (0.075 μg/gcrea) for 2-OH-phenanthrene, 0.131 μg/L (0.11Germany. OBJECTIVES Evaluate the influence of rupture of membranes (spontaneous or artificial) on fetal heart rate. Secondary objectives were to compare spontaneous and artificial ruptures and to investigate the risk factors associated with the occurrence of abnormalities of fetal heart rate (FHR). METHODS This is a monocentric retrospective study (Lille, France) from January to March 2018. All low-risk pregnancies with cephalic presentation, spontaneous labor, gestational age more than 37 weeks of amenorrhea, singleton pregnancy, absence of maternal or fetal pathology were included. The elements sought were the occurrence of bradycardia, tachycardia, decelerations (early, late, typical variable, atypical variable, prolonged) and abnormal variability. FHR was analyzed one hour before and one hour after rupture. The groups with and without abnormalities of FHR were compared according to the type of rupture. RESULTS 233 patients were included. 44.54% (n=129, p less then 0.001) showed abnormalities of FHR after rupture of membranes. In the fetal heart rate time study after the rupture event, prolonged decelerations were more frequent in the first quarter hour compared to the second quarter hour. There was significantly more risk of abnormalities of fetal heart rate if the fetal heart rate before the rupture of membranes was already pathological, as well as if the time between rupture and delivery was short. The type of rupture, artificial or spontaneous, was not a risk factor. CONCLUSION The rupture of membranes increased the occurrence of abnormalities of FHR. However, there is no more deleterious impact of one type of rupture than the other. Performing a feticide as part of termination of late pregnancy is recommended in many countries. Feticide avoids a live birth of a severely affected premature newborn and prevents fetal pain. There are limited data on feticide procedures since only a few countries in the world authorize late termination of pregnancy. The objective of this review was to assess the most appropriate feticide procedure based on published data during the last thirty years.  https://www.selleckchem.com/products/sirtinol.html  Administration of an initial fetal analgesia followed by a lethal lidocaine injection through the umbilical cord, under ultrasound guidance, appears to be the most effective, safe and ethical way to perform feticide. According to the current knowledge regarding the risk of fetal pain and survival of extremely preterm infants, a feticide should be discussed as early as 20-22 weeks of gestation. Liposomes, lipid-based vesicular systems, have attracted major interest as a means to improve drug delivery to various organs and tissues in the human body. Recent literature highlights the benefits of liposomes for use as drug delivery systems, including encapsulating of both hydrophobic and hydrophilic cargos, passive and active targeting, enhanced drug bioavailability and therapeutic effects, reduced systemic side effects, improved cargo penetration into the target tissue and triggered contents release. Pioneering work of liposomes researchers led to introduction of long-circulating, ligand-targeted and triggered release liposomes, as well as, liposomes containing nucleic acids and vesicles containing combination of cargos. Altogether, these findings have led to widespread application of liposomes in a plethora of areas from cancer to conditions such as cardiovascular, neurologic, respiratory, skin, autoimmune and eye disorders. There are numerous review articles on the application of liposomes in treatment of cancer, which seems the primary focus, whereas other diseases also benefit from liposome-mediated treatments.